TY - JOUR
T1 - Validity of bioelectrical impedance analysis to assess fat-free mass in patients with head and neck cancer
T2 - An exploratory study
AU - Jager-Wittenaar, Harriët
AU - Dijkstra, Pieter U.
AU - Earthman, Carrie P.
AU - Krijnen, Wim P.
AU - Langendijk, Johannes A.
AU - Van Der Laan, Bernard F.A.M.
AU - Pruim, Jan
AU - Roodenburg, Jan L.N.
PY - 2014/4
Y1 - 2014/4
N2 - ABSTRACT: Background The purpose of this study was to validate bioelectrical impedance analysis (BIA) using the Geneva equation for fat-free mass (FFM) in patients with head and neck cancer. Methods In 24 patients with head and neck cancer, agreement between BIA (FFMBIA) and dual energy x-ray absorptiometry (FFMDXA) 1 week before (T0), 1 month (T1), and 4 months (T2) after cancer treatment was analyzed. Results FFMBIA did not differ from FFMDXA (mean difference 0.71 ± 1.9, 0.30 ± 1.9, and 0.02 ± 2.1 kg) at any time point. Only at T0, mean FFM correlated to the difference between FFMDXA and FFMBIA (r = 0.48; p =.017). Limits of agreement were 3.8, 3.7, and 4.1 kg, respectively. Concordance Correlation Coefficients were 0.98 at all time points. Conclusion BIA may be used to assess FFM with reasonable validity based on mean-level comparisons, but differences between BIA and DXA may vary by about 4 kg in an individual patient. These results require confirmation in a larger sample of patients with head and neck cancer.
AB - ABSTRACT: Background The purpose of this study was to validate bioelectrical impedance analysis (BIA) using the Geneva equation for fat-free mass (FFM) in patients with head and neck cancer. Methods In 24 patients with head and neck cancer, agreement between BIA (FFMBIA) and dual energy x-ray absorptiometry (FFMDXA) 1 week before (T0), 1 month (T1), and 4 months (T2) after cancer treatment was analyzed. Results FFMBIA did not differ from FFMDXA (mean difference 0.71 ± 1.9, 0.30 ± 1.9, and 0.02 ± 2.1 kg) at any time point. Only at T0, mean FFM correlated to the difference between FFMDXA and FFMBIA (r = 0.48; p =.017). Limits of agreement were 3.8, 3.7, and 4.1 kg, respectively. Concordance Correlation Coefficients were 0.98 at all time points. Conclusion BIA may be used to assess FFM with reasonable validity based on mean-level comparisons, but differences between BIA and DXA may vary by about 4 kg in an individual patient. These results require confirmation in a larger sample of patients with head and neck cancer.
KW - bioelectrical impedance analysis
KW - body composition
KW - fat-free mass
KW - head and neck cancer
KW - validity
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U2 - 10.1002/hed.23336
DO - 10.1002/hed.23336
M3 - Article
C2 - 23595994
AN - SCOPUS:84896132311
SN - 1043-3074
VL - 36
SP - 585
EP - 591
JO - Head and Neck
JF - Head and Neck
IS - 4
ER -
