Validation of whole blood rapid diagnosis test for hepatitis b

Jose D. Debes; Gertine van Oord; Andre Boonstra

doi:10.5334/aogh.2866

Validation of whole blood rapid diagnosis test for hepatitis b

Jose D. Debes, Gertine van Oord, Andre Boonstra

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Letter › peer-review

Abstract

We recently published a report validating point-of-care rapid diagnostic tests (RDT) for the diagnosis of Hepatitis B virus (HBV) infection in serum. In the current report, we validated a whole-blood RDT for HBsAg in the form of a test-strip. The test was validated in 55 HBV positive individuals across all geno-types other than F, and in 20 HBV negative individuals in the Netherlands. The RDT showed 100% sensi-tivity and specificity. The low cost and use in whole blood allows this RDT to be useful in resource-limited locations, further validation in such settings will be of importance.

Original language	English (US)
Article number	53
Journal	Annals of global health
Volume	86
Issue number	1
DOIs	https://doi.org/10.5334/aogh.2866
State	Published - 2020

Bibliographical note

Funding Information:
This work was supported the Robert Wood Johnson Foundation, AFMDP, Mitialto Foundation and NIH-NCI R21 CA215883-01A1 all to JDD. Funding sponsors had no role in the production of this manuscript.

Publisher Copyright:
© 2020 The Author(s).

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title = "Validation of whole blood rapid diagnosis test for hepatitis b",

abstract = "We recently published a report validating point-of-care rapid diagnostic tests (RDT) for the diagnosis of Hepatitis B virus (HBV) infection in serum. In the current report, we validated a whole-blood RDT for HBsAg in the form of a test-strip. The test was validated in 55 HBV positive individuals across all geno-types other than F, and in 20 HBV negative individuals in the Netherlands. The RDT showed 100% sensi-tivity and specificity. The low cost and use in whole blood allows this RDT to be useful in resource-limited locations, further validation in such settings will be of importance.",

author = "Debes, {Jose D.} and {van Oord}, Gertine and Andre Boonstra",

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AU - Debes, Jose D.

AU - van Oord, Gertine

AU - Boonstra, Andre

N1 - Funding Information: This work was supported the Robert Wood Johnson Foundation, AFMDP, Mitialto Foundation and NIH-NCI R21 CA215883-01A1 all to JDD. Funding sponsors had no role in the production of this manuscript. Publisher Copyright: © 2020 The Author(s).

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N2 - We recently published a report validating point-of-care rapid diagnostic tests (RDT) for the diagnosis of Hepatitis B virus (HBV) infection in serum. In the current report, we validated a whole-blood RDT for HBsAg in the form of a test-strip. The test was validated in 55 HBV positive individuals across all geno-types other than F, and in 20 HBV negative individuals in the Netherlands. The RDT showed 100% sensi-tivity and specificity. The low cost and use in whole blood allows this RDT to be useful in resource-limited locations, further validation in such settings will be of importance.

AB - We recently published a report validating point-of-care rapid diagnostic tests (RDT) for the diagnosis of Hepatitis B virus (HBV) infection in serum. In the current report, we validated a whole-blood RDT for HBsAg in the form of a test-strip. The test was validated in 55 HBV positive individuals across all geno-types other than F, and in 20 HBV negative individuals in the Netherlands. The RDT showed 100% sensi-tivity and specificity. The low cost and use in whole blood allows this RDT to be useful in resource-limited locations, further validation in such settings will be of importance.

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Validation of whole blood rapid diagnosis test for hepatitis b

Abstract

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