Validation of the NIH Toolbox-Cognition Battery against legacy neurocognitive measures in adults with cognitive impairments: An exploratory analysis

Emily A. Kringle; Enrico M. Novelli; Meryl A. Butters; Elizabeth R. Skidmore

doi:10.1017/S1355617722000406

Validation of the NIH Toolbox-Cognition Battery against legacy neurocognitive measures in adults with cognitive impairments: An exploratory analysis

Emily A. Kringle, Enrico M. Novelli, Meryl A. Butters, Elizabeth R. Skidmore

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objective: The purpose of this exploratory study was to describe associations between NIH Toolbox-Cognition Battery subtests and legacy measures of neurocognitive function in two samples with neurological conditions (stroke and sickle cell disease (SCD)). Method: This exploratory secondary analysis uses data from two studies that assessed cognition at one time point using the NIH Toolbox-Cognition Battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and subtests from the Delis-Kaplan Executive Functions System (DKEFS). People with stroke (n = 26) and SCD (n = 64) were included. Associations between the NIH Toolbox-Cognition Battery subtests and corresponding legacy measures were examined using linear correlations, Bland-Altman analysis, and Lin's Concordance Correlation Coefficient. Results: Linear correlations and Lin's Concordance Correlation Coefficient were poor to strong in both samples on NIH Toolbox-CB subtests: Flanker Inhibitory Control and Attention (r =.35 to.48, Lin CCC =.27 to.37), Pattern Comparison Processing Speed (r =.40 to.65, Lin CCC =.37 to.62), Picture Sequence Memory (r =.19 to.55, Lin CCC =.18 to.48), Dimensional Change Card Sort (r =.39 to.77, Lin CCC =.38 to.63), Fluid Cognition Composite (r =.88 to.90, Lin CCC =.60 to.79), and Total Cognition Composite (r =.64 to.83, Lin CCC =.60 to.78). Bland-Altman analyses demonstrated wide limits of agreement across all subtests (-3.17 to 3.78). Conclusions: The NIH Toolbox-Cognition Battery subtests may behave similarly to legacy measures as an overall assessment of cognition across samples at risk for neurological impairment. Findings should be replicated across additional clinical samples.

Original language	English (US)
Pages (from-to)	472-479
Number of pages	8
Journal	Journal of the International Neuropsychological Society
Volume	29
Issue number	5
DOIs	https://doi.org/10.1017/S1355617722000406
State	Published - Jun 5 2023
Externally published	Yes

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Heart Lung and Blood Institute (R01 HL127107-01A1, T32 HL134634, K23 HL159240), the National Center for Advancing Translational Sciences (UL1 TR001857) of the National Institutes of Health, the National Institute on Disability, Independent Living and Rehabilitation Research (90AR5023), the University of Pittsburgh School of Health and Rehabilitation Sciences PhD Student Award, and University of Pittsburgh Occupational Therapy Department Funds. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the National Institute on Disability, Independent Living and Rehabilitation Research, or the University of Pittsburgh.

Publisher Copyright:
Copyright © INS. Published by Cambridge University Press, 2022.

Keywords

anemia
cognition
comprehension
executive function
language
memory
perception
sickle cell
stroke

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1017/S1355617722000406

Find It

Find It at U of M Libraries

Cite this

Validation of the NIH Toolbox-Cognition Battery against legacy neurocognitive measures in adults with cognitive impairments: An exploratory analysis. / Kringle, Emily A.; Novelli, Enrico M.; Butters, Meryl A. et al.
In: Journal of the International Neuropsychological Society, Vol. 29, No. 5, 05.06.2023, p. 472-479.

Research output: Contribution to journal › Article › peer-review

@article{1e32a8efad5b42b3a0ee7032a0b149d0,

title = "Validation of the NIH Toolbox-Cognition Battery against legacy neurocognitive measures in adults with cognitive impairments: An exploratory analysis",

abstract = "Objective: The purpose of this exploratory study was to describe associations between NIH Toolbox-Cognition Battery subtests and legacy measures of neurocognitive function in two samples with neurological conditions (stroke and sickle cell disease (SCD)). Method: This exploratory secondary analysis uses data from two studies that assessed cognition at one time point using the NIH Toolbox-Cognition Battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and subtests from the Delis-Kaplan Executive Functions System (DKEFS). People with stroke (n = 26) and SCD (n = 64) were included. Associations between the NIH Toolbox-Cognition Battery subtests and corresponding legacy measures were examined using linear correlations, Bland-Altman analysis, and Lin's Concordance Correlation Coefficient. Results: Linear correlations and Lin's Concordance Correlation Coefficient were poor to strong in both samples on NIH Toolbox-CB subtests: Flanker Inhibitory Control and Attention (r =.35 to.48, Lin CCC =.27 to.37), Pattern Comparison Processing Speed (r =.40 to.65, Lin CCC =.37 to.62), Picture Sequence Memory (r =.19 to.55, Lin CCC =.18 to.48), Dimensional Change Card Sort (r =.39 to.77, Lin CCC =.38 to.63), Fluid Cognition Composite (r =.88 to.90, Lin CCC =.60 to.79), and Total Cognition Composite (r =.64 to.83, Lin CCC =.60 to.78). Bland-Altman analyses demonstrated wide limits of agreement across all subtests (-3.17 to 3.78). Conclusions: The NIH Toolbox-Cognition Battery subtests may behave similarly to legacy measures as an overall assessment of cognition across samples at risk for neurological impairment. Findings should be replicated across additional clinical samples.",

keywords = "anemia, cognition, comprehension, executive function, language, memory, perception, sickle cell, stroke",

author = "Kringle, {Emily A.} and Novelli, {Enrico M.} and Butters, {Meryl A.} and Skidmore, {Elizabeth R.}",

note = "Funding Information: Research reported in this publication was supported by the National Heart Lung and Blood Institute (R01 HL127107-01A1, T32 HL134634, K23 HL159240), the National Center for Advancing Translational Sciences (UL1 TR001857) of the National Institutes of Health, the National Institute on Disability, Independent Living and Rehabilitation Research (90AR5023), the University of Pittsburgh School of Health and Rehabilitation Sciences PhD Student Award, and University of Pittsburgh Occupational Therapy Department Funds. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the National Institute on Disability, Independent Living and Rehabilitation Research, or the University of Pittsburgh. Publisher Copyright: Copyright {\textcopyright} INS. Published by Cambridge University Press, 2022.",

year = "2023",

month = jun,

day = "5",

doi = "10.1017/S1355617722000406",

language = "English (US)",

volume = "29",

pages = "472--479",

journal = "Journal of the International Neuropsychological Society",

issn = "1355-6177",

publisher = "Cambridge University Press",

number = "5",

}

TY - JOUR

T1 - Validation of the NIH Toolbox-Cognition Battery against legacy neurocognitive measures in adults with cognitive impairments

T2 - An exploratory analysis

AU - Kringle, Emily A.

AU - Novelli, Enrico M.

AU - Butters, Meryl A.

AU - Skidmore, Elizabeth R.

N1 - Funding Information: Research reported in this publication was supported by the National Heart Lung and Blood Institute (R01 HL127107-01A1, T32 HL134634, K23 HL159240), the National Center for Advancing Translational Sciences (UL1 TR001857) of the National Institutes of Health, the National Institute on Disability, Independent Living and Rehabilitation Research (90AR5023), the University of Pittsburgh School of Health and Rehabilitation Sciences PhD Student Award, and University of Pittsburgh Occupational Therapy Department Funds. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the National Institute on Disability, Independent Living and Rehabilitation Research, or the University of Pittsburgh. Publisher Copyright: Copyright © INS. Published by Cambridge University Press, 2022.

PY - 2023/6/5

Y1 - 2023/6/5

N2 - Objective: The purpose of this exploratory study was to describe associations between NIH Toolbox-Cognition Battery subtests and legacy measures of neurocognitive function in two samples with neurological conditions (stroke and sickle cell disease (SCD)). Method: This exploratory secondary analysis uses data from two studies that assessed cognition at one time point using the NIH Toolbox-Cognition Battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and subtests from the Delis-Kaplan Executive Functions System (DKEFS). People with stroke (n = 26) and SCD (n = 64) were included. Associations between the NIH Toolbox-Cognition Battery subtests and corresponding legacy measures were examined using linear correlations, Bland-Altman analysis, and Lin's Concordance Correlation Coefficient. Results: Linear correlations and Lin's Concordance Correlation Coefficient were poor to strong in both samples on NIH Toolbox-CB subtests: Flanker Inhibitory Control and Attention (r =.35 to.48, Lin CCC =.27 to.37), Pattern Comparison Processing Speed (r =.40 to.65, Lin CCC =.37 to.62), Picture Sequence Memory (r =.19 to.55, Lin CCC =.18 to.48), Dimensional Change Card Sort (r =.39 to.77, Lin CCC =.38 to.63), Fluid Cognition Composite (r =.88 to.90, Lin CCC =.60 to.79), and Total Cognition Composite (r =.64 to.83, Lin CCC =.60 to.78). Bland-Altman analyses demonstrated wide limits of agreement across all subtests (-3.17 to 3.78). Conclusions: The NIH Toolbox-Cognition Battery subtests may behave similarly to legacy measures as an overall assessment of cognition across samples at risk for neurological impairment. Findings should be replicated across additional clinical samples.

AB - Objective: The purpose of this exploratory study was to describe associations between NIH Toolbox-Cognition Battery subtests and legacy measures of neurocognitive function in two samples with neurological conditions (stroke and sickle cell disease (SCD)). Method: This exploratory secondary analysis uses data from two studies that assessed cognition at one time point using the NIH Toolbox-Cognition Battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and subtests from the Delis-Kaplan Executive Functions System (DKEFS). People with stroke (n = 26) and SCD (n = 64) were included. Associations between the NIH Toolbox-Cognition Battery subtests and corresponding legacy measures were examined using linear correlations, Bland-Altman analysis, and Lin's Concordance Correlation Coefficient. Results: Linear correlations and Lin's Concordance Correlation Coefficient were poor to strong in both samples on NIH Toolbox-CB subtests: Flanker Inhibitory Control and Attention (r =.35 to.48, Lin CCC =.27 to.37), Pattern Comparison Processing Speed (r =.40 to.65, Lin CCC =.37 to.62), Picture Sequence Memory (r =.19 to.55, Lin CCC =.18 to.48), Dimensional Change Card Sort (r =.39 to.77, Lin CCC =.38 to.63), Fluid Cognition Composite (r =.88 to.90, Lin CCC =.60 to.79), and Total Cognition Composite (r =.64 to.83, Lin CCC =.60 to.78). Bland-Altman analyses demonstrated wide limits of agreement across all subtests (-3.17 to 3.78). Conclusions: The NIH Toolbox-Cognition Battery subtests may behave similarly to legacy measures as an overall assessment of cognition across samples at risk for neurological impairment. Findings should be replicated across additional clinical samples.

KW - anemia

KW - cognition

KW - comprehension

KW - executive function

KW - language

KW - memory

KW - perception

KW - sickle cell

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85159729395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85159729395&partnerID=8YFLogxK

U2 - 10.1017/S1355617722000406

DO - 10.1017/S1355617722000406

M3 - Article

C2 - 36062530

AN - SCOPUS:85159729395

SN - 1355-6177

VL - 29

SP - 472

EP - 479

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

IS - 5

ER -

Validation of the NIH Toolbox-Cognition Battery against legacy neurocognitive measures in adults with cognitive impairments: An exploratory analysis

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this