TY - JOUR
T1 - Validation of rapid HIV antibody tests in 5 African Countries
AU - Piwowar-Manning, Estelle M.
AU - Tustin, Nancy B.
AU - Sikateyo, Physiwell
AU - Kamwendo, Debbie
AU - Chipungu, Chifundo
AU - Maharaj, Rashika
AU - Mushanyu, Jabulani
AU - Richardson, Barbra A.
AU - Hillier, Sharon
AU - Jackson, J. Brooks
PY - 2010/5
Y1 - 2010/5
N2 - The sensitivity and specificity of 3 rapid HIV antibody tests were assessed at 5 clinical trial sites in Africa and 1 site in the United States using a minimum of 100 HIV antibody positive samples and 100 HIV antibody negative samples at each site. The overall sensitivity and specificity for the OraSure OraQuick, Abbott Determine, and Trinity Unigold tests were 99.3%, 99.8%, and 98.5%, respectively, and 99.3%, 99.4%, and 99.5%, respectively. There were no instances at any site in which false-negative or false-positive results were obtained for the same sample on more than 1 rapid test kit. The results of this study provide assurance that for these diverse sites in Africa, the accuracy of these kits is quite good. Given the excellent accuracy, relatively fast turnaround time, and minimal infrastructure required, these rapid tests for HIV antibody provide a very attractive and accurate testing format.
AB - The sensitivity and specificity of 3 rapid HIV antibody tests were assessed at 5 clinical trial sites in Africa and 1 site in the United States using a minimum of 100 HIV antibody positive samples and 100 HIV antibody negative samples at each site. The overall sensitivity and specificity for the OraSure OraQuick, Abbott Determine, and Trinity Unigold tests were 99.3%, 99.8%, and 98.5%, respectively, and 99.3%, 99.4%, and 99.5%, respectively. There were no instances at any site in which false-negative or false-positive results were obtained for the same sample on more than 1 rapid test kit. The results of this study provide assurance that for these diverse sites in Africa, the accuracy of these kits is quite good. Given the excellent accuracy, relatively fast turnaround time, and minimal infrastructure required, these rapid tests for HIV antibody provide a very attractive and accurate testing format.
KW - Africa
KW - HIV antibody
KW - Rapid test
KW - Sensitivity
KW - Specificity
UR - http://www.scopus.com/inward/record.url?scp=77953678410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953678410&partnerID=8YFLogxK
U2 - 10.1177/1545109710368151
DO - 10.1177/1545109710368151
M3 - Article
C2 - 20530471
AN - SCOPUS:77953678410
SN - 1545-1097
VL - 9
SP - 170
EP - 172
JO - Journal of the International Association of Physicians in AIDS Care
JF - Journal of the International Association of Physicians in AIDS Care
IS - 3
ER -
