Validation and Implementation of an Ordering Alert to Improve the Efficiency of Monoclonal Gammopathy Evaluation

Sacha N. Uljon, Daimon P. Simmons, Joseph W. Rudolf, Jason M. Baron, Sayon Dutta, Dustin S. McEvoy, Mandakolathur Murali, Anand S. Dighe

Research output: Contribution to journalArticlepeer-review


Objectives: To evaluate the use of a provider ordering alert to improve laboratory efficiency and reduce costs. Methods: We conducted a retrospective study to assess the use of an institutional reflex panel for monoclonal gammopathy evaluation. We then created a clinical decision support (CDS) alert to educate and encourage providers to change their less-efficient orders to the reflex panel. Results: Our retrospective analysis demonstrated that an institutional reflex panel could be safely substituted for a less-efficient and higher-cost panel. The implemented CDS alert resulted in 79% of providers changing their high-cost order panel to an order panel based on the reflex algorithm. Conclusions: The validated decision support alert demonstrated high levels of provider acceptance and directly led to operational and cost savings within the laboratory. Furthermore, these studies highlight the value of laboratory involvement with CDS efforts to provide agile and targeted provider ordering assistance.

Original languageEnglish (US)
Pages (from-to)396-406
Number of pages11
JournalAmerican journal of clinical pathology
Issue number3
StatePublished - Feb 8 2020

Bibliographical note

Publisher Copyright:
© 2019 American Society for Clinical Pathology, 2019. All rights reserved. For permissions, please e-mail:


  • Clinical decision support
  • Monoclonal gammopathy
  • Serum protein electrophoresis
  • Utilization management

PubMed: MeSH publication types

  • Journal Article


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