Vagus nerve stimulation (VNS) for depression: What do we know now and what should be done next?

Ziad Nahas, Carol Burns, Milton J. Foust, Baron Short, Tal Herbsman, Mark S. George

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Vagus nerve stimulation (VNS) therapy is the first US Food and Drug Administration-approved somatic clinical intervention for treatment-resistant depression (TRD). Long-term open data suggest a sustainable antidepressant response over time. Here we review the clinical data that exist so far and their limitations. We also discuss guidelines that may inform the clinical utilization of this procedure. Further clinical studies, in addition to prospective cost utilization and health economic investigations, are needed to better understand VNS therapy and the impact it holds on TRD care.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalCurrent psychiatry reports
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2006

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