Vagus nerve stimulation therapy: A research update

Mark S. George, Z. Nahas, D. E. Bohning, F. A. Kozel, B. Anderson, J. H. Chae, M. Lomarev, S. Denslow, X. Li, C. Mu

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Over the past 5 years, and especially within the last year, there has been a rapid expansion of vagus nerve stimulation (VNS)-related preclinical research, as well as clinical studies in indications other than epilepsy. The research advances in understanding VNS are occurring in the midst of a blossoming of other forms of therapeutic brain stimulation, such as electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS). In general, improved understanding of the neurobiological effects of VNS therapy as a function of the different use parameters (frequency, intensity, pulse width, duration, dose) is beginning to guide clinical use and help determine which diseases, in addition to epilepsy, VNS might treat.

Original languageEnglish (US)
Pages (from-to)S56-S61
JournalNeurology
Volume59
Issue number6 SUPPL. 4
DOIs
StatePublished - Sep 24 2002

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