Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness

The i3C Consortium Study

Juha Koskinen, Markus Juonala, Terence Dwyer, Alison Venn, Janina Petkeviciene, Indrė Čeponienė, Lydia Bazzano, Wei Chen, Matthew A. Sabin, Trudy L. Burns, Jorma S.A. Viikari, Jessica G. Woo, Elaine M. Urbina, Ronald Prineas, Nina Hutri-Kähönen, Alan R Sinaiko, David R Jacobs Jr, Julia Steinberger, Stephen Daniels, Olli Raitakari & 1 others Costan G. Magnussen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Childhood blood pressure (BP) levels predict adult subclinical atherosclerosis. However, the best childhood BP component for prediction has not been determined. This study comprised 5925 participants aged 3 to 18 years from 6 cohorts who were followed into adulthood (mean follow-up 25.8±6.2 years). Childhood BP was measured by using a standard mercury sphygmomanometer in all cohorts. Study-specific carotid intima-media thickness ≥90th percentile was used to define subclinical atherosclerosis. Per SD change in the predictor, childhood systolic BP (SBP; age- and sex-adjusted odds ratio [95% CI], 1.24 [1.13-1.37]), mean arterial pressure (1.10 [1.07-1.13]), and pulse pressure (1.15 [1.05-1.27]) were associated with increased adulthood intima-media thickness. In age- and sex-adjusted analyses, area under the receiver operating characteristic curves for SBP (C value [95% CI], 0.677 [0.657-0.704]) showed significantly improved prediction compared with diastolic BP (0.669 [0.646-0.693], P=0.006) or mean arterial pressure (0.674 [0.653-0.699], P=0.01). Pulse pressure provided a C value that was not different from SBP (0.676 [0.653-0.699], P=0.16). Combining different BP components did not improve prediction over SBP measurement alone. Based on the associations with adult carotid intima-media thickness, cut points for elevated SBP were 105 mm Hg for 3- to 6-year-old boys, 108 mm Hg for 3- to 6-year-old girls, 108 mm Hg for 7- to 12-year-old boys, 106 mm Hg for 7- to 12-year-old girls, 123 mm Hg for 13- to 18-year-old boys, and 115 mm Hg for 13- to 18-year-old girls. Our analyses suggest that several childhood BP measurement components are related to adulthood carotid intima-media thickness. Of these, SBP provided the best predictive ability.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalHypertension
Volume73
Issue number2
DOIs
StatePublished - Jan 1 2019

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Carotid Intima-Media Thickness
Blood Pressure
Atherosclerosis
Arterial Pressure
Sphygmomanometers
Mercury
ROC Curve
Odds Ratio

Keywords

  • arterial pressure
  • atherosclerosis
  • blood pressure
  • epidemiology
  • pediatrics

Cite this

Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness : The i3C Consortium Study. / Koskinen, Juha; Juonala, Markus; Dwyer, Terence; Venn, Alison; Petkeviciene, Janina; Čeponienė, Indrė; Bazzano, Lydia; Chen, Wei; Sabin, Matthew A.; Burns, Trudy L.; Viikari, Jorma S.A.; Woo, Jessica G.; Urbina, Elaine M.; Prineas, Ronald; Hutri-Kähönen, Nina; Sinaiko, Alan R; Jacobs Jr, David R; Steinberger, Julia; Daniels, Stephen; Raitakari, Olli; Magnussen, Costan G.

In: Hypertension, Vol. 73, No. 2, 01.01.2019, p. 335-341.

Research output: Contribution to journalArticle

Koskinen, J, Juonala, M, Dwyer, T, Venn, A, Petkeviciene, J, Čeponienė, I, Bazzano, L, Chen, W, Sabin, MA, Burns, TL, Viikari, JSA, Woo, JG, Urbina, EM, Prineas, R, Hutri-Kähönen, N, Sinaiko, AR, Jacobs Jr, DR, Steinberger, J, Daniels, S, Raitakari, O & Magnussen, CG 2019, 'Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness: The i3C Consortium Study', Hypertension, vol. 73, no. 2, pp. 335-341. https://doi.org/10.1161/HYPERTENSIONAHA.118.12225
Koskinen, Juha ; Juonala, Markus ; Dwyer, Terence ; Venn, Alison ; Petkeviciene, Janina ; Čeponienė, Indrė ; Bazzano, Lydia ; Chen, Wei ; Sabin, Matthew A. ; Burns, Trudy L. ; Viikari, Jorma S.A. ; Woo, Jessica G. ; Urbina, Elaine M. ; Prineas, Ronald ; Hutri-Kähönen, Nina ; Sinaiko, Alan R ; Jacobs Jr, David R ; Steinberger, Julia ; Daniels, Stephen ; Raitakari, Olli ; Magnussen, Costan G. / Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness : The i3C Consortium Study. In: Hypertension. 2019 ; Vol. 73, No. 2. pp. 335-341.
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AU - Venn, Alison

AU - Petkeviciene, Janina

AU - Čeponienė, Indrė

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AU - Sabin, Matthew A.

AU - Burns, Trudy L.

AU - Viikari, Jorma S.A.

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AU - Urbina, Elaine M.

AU - Prineas, Ronald

AU - Hutri-Kähönen, Nina

AU - Sinaiko, Alan R

AU - Jacobs Jr, David R

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AU - Daniels, Stephen

AU - Raitakari, Olli

AU - Magnussen, Costan G.

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