UTE-SPECIAL for 3D localization at an echo time of 4 ms on a clinical 3 T scanner

Karl Landheer, Ralph Noeske, Michael Garwood, Christoph Juchem

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Reducing the echo time of magnetic resonance spectroscopy experiments is appealing because it increases the available signal and reduces J-evolution of coupled metabolites. In this manuscript a novel sequence, referred to as Ultrashort echo TimE, SPin ECho, full Intensity Acquired Localized (UTE-SPECIAL), is described which is able to achieve ultrashort echo times (4 ms) on a standard clinical 3 T MR system while recovering the entirety of the available magnetization. UTE-SPECIAL obtains full 3D spatial localization through a 2D adiabatic inversion pulse which is cycled “on” and “off” every other repetition, in combination with a slice-selective excitation pulse. In addition to an ultrashort echo time, UTE-SPECIAL has negligible chemical shift displacement artefact and, because it uses no slice-selective refocusing pulse, has no signal cancellation at the borders for J-coupled metabolites. Spectra with an ultrashort echo time of 4 ms are demonstrated in vivo at 3 T, as well as J-resolved spectra obtained in a phantom and a healthy volunteer.

Original languageEnglish (US)
Article number106670
JournalJournal of Magnetic Resonance
Volume311
DOIs
StatePublished - Feb 2020

Bibliographical note

Funding Information:
Special thanks to New York State Psychiatric Institute (NYSPI) and Feng Liu, PhD, for their facilities and technical support and Martin Gajdošík, PhD, for fruitful discussions and input. This work was supported by the National Multiple Sclerosis Society (NMSS, RG-5319 ) and by NIH grant P41 EB027061 .

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • In vivo magnetic resonance spectroscopy
  • J-coupling
  • SPECIAL
  • Ultrashort TE MRS

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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