UTE-SPECIAL for 3D localization at an echo time of 4 ms on a clinical 3 T scanner

Karl Landheer, Ralph Noeske, Michael Garwood, Christoph Juchem

Research output: Contribution to journalArticlepeer-review


Reducing the echo time of magnetic resonance spectroscopy experiments is appealing because it increases the available signal and reduces J-evolution of coupled metabolites. In this manuscript a novel sequence, referred to as Ultrashort echo TimE, SPin ECho, full Intensity Acquired Localized (UTE-SPECIAL), is described which is able to achieve ultrashort echo times (4 ms) on a standard clinical 3 T MR system while recovering the entirety of the available magnetization. UTE-SPECIAL obtains full 3D spatial localization through a 2D adiabatic inversion pulse which is cycled “on” and “off” every other repetition, in combination with a slice-selective excitation pulse. In addition to an ultrashort echo time, UTE-SPECIAL has negligible chemical shift displacement artefact and, because it uses no slice-selective refocusing pulse, has no signal cancellation at the borders for J-coupled metabolites. Spectra with an ultrashort echo time of 4 ms are demonstrated in vivo at 3 T, as well as J-resolved spectra obtained in a phantom and a healthy volunteer.

Original languageEnglish (US)
Article number106670
JournalJournal of Magnetic Resonance
StatePublished - Feb 2020


  • In vivo magnetic resonance spectroscopy
  • J-coupling
  • Ultrashort TE MRS

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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