Using Simulation to Help Specify Design Parameters for Vacuum-Assisted Needle Biopsy Systems

Xuelian Gu, Fangqiu Hu, Chi Lun Lin, Arthur Erdman, Licheng Lu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Needle biopsy is a routine medical procedure for examining tissue or biofluids for the presence of disease using standard methods of pathology. The finite element analysis (FEA) methodology can provide guidance for optimizing the geometric parameters. The needle biopsy is simulated and analyzed while varying the needle angle, the aperture size and the slice-push ratio k. The results indicate that tissue reaction force in the axial direction of needle gradually decreases, and the stress and strain are more concentrated at the tip of needle with the increases of tip angle; the tissue reaction force decreases, and the torque increases while the slice-push ratio increases; and higher slice-push ratio can increase the peak stress concentration on the cutting edge and deformation of tissue; in the process of core needle cutting, increasing slice-push ratio can reduce the tissue reaction force significantly. While the aperture on distal wall of outer cannula becomes wider, the tissue reaction force increases significantly, and the cutting process will be more unstable. The results have the potential to provide important insight for improving the needle biopsy design process.

Original languageEnglish (US)
Article number014502
JournalJournal of Medical Devices, Transactions of the ASME
Issue number1
StatePublished - Mar 1 2019

Bibliographical note

Funding Information:
The second and third authors were partially supported by the National Science Foundation (IIS-1251069) and the National Institutes of Health (1R01EB018205-01).

Publisher Copyright:
© 2019 by ASME.


  • biomechanics
  • finite element analysis
  • needle biopsy


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