Using proteomics and network analysis to elucidate the consequences of synaptic protein oxidation in a PS1+AβPP mouse model of Alzheimer's disease

Keyphrases

• Network Analysis 100%
• Alzheimer's Disease 100%
• Proteomic Analysis 100%
• Alzheimer's Disease Model 100%
• Protein Oxidation 100%
• Synaptic Proteins 100%
• APP Mice 100%
• Protein Carbonyls 66%
• High-throughput 33%
• Statistical Model 33%
• Aging 33%
• Transgenic Mice 33%
• Oxidative Stress 33%
• Neurodegeneration 33%
• Oxidative Modification 33%
• Protein Targeting 33%
• Bioinformatics Tools 33%
• Genetic Background 33%
• Cell Death 33%
• Bioinformatics Methods 33%
• Proteomics Data 33%
• Oxidative Damage 33%
• Protein Identification 33%
• Diverse Sample 33%
• Transcription Regulation 33%
• Inducible Nitric Oxide Synthase 33%
• Database Search 33%
• Relative Abundance 33%
• Search Algorithm 33%
• Protein Network 33%
• Probability-based 33%
• Vesicle Trafficking 33%
• Oxidized Proteins 33%
• Disease Database 33%
• Shotgun Proteomics 33%
• Hypothesis-driven Research 33%
• Proteomic Database 33%
• Integrin Signaling Pathway 33%
• APP Transgenic Mice 33%
• Expression Abundance 33%
• False Identification 33%
• Neuronal Impairment 33%
• Protein Assignment 33%
• Network Component Analysis 33%
• Age-related Neurodegeneration 33%

Biochemistry, Genetics and Molecular Biology

• Mouse Model 100%
• Proteomics 100%
• Transgenic Mouse 66%
• Signal Transduction 33%
• Oxidative Stress 33%
• Genetic Background 33%
• Protein Carbonylation 33%
• Transcription Regulation 33%
• Shotgun Proteomics 33%
• Cell Death 33%
• Integrin 33%

Neuroscience

• Proteomics 100%
• Alzheimer's Disease 100%
• Cell Signaling 25%
• Integrin 25%
• Age-Related Neurodegenerative Disorder 25%
• Oxidative Stress 25%
• Transcription Regulation 25%
• Protein Carbonylation 25%
• Cell Death 25%
• Neurodegeneration 25%