Using high frequency transcranial random noise stimulation to modulate face memory performance in younger and older adults

Lessons learnt from mixed findings

Tegan Penton, Sarah Bate, Kirsten Dalrymple, Thomas Reed, Maria Kelly, Sheina Godovich, Marin Tamm, Bradley Duchaine, Michael J. Banissy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

High-frequency transcranial random noise stimulation (tRNS) has been shown to improve a range of cognitive and perceptual abilities. Here we sought to examine the effects of a single session of tRNS targeted at the ventrolateral prefrontal cortices (VLPFC) on face memory in younger and older adults. To do so, we conducted three experiments. In Experiment 1, we found that younger adults receiving active tRNS outperformed those receiving sham stimulation (i.e., using a between-participant factor for stimulation condition; Experiment 1). This effect was not observed for object memory (car memory) in younger adults (Experiment 2), indicating that the effect is not a general memory effect. In Experiment 3, we sought to replicate the effects of Experiment 1 using a different design (within-participant factor of stimulation - active or sham tRNS to the same individual) and to extend the study by including older adult participants. In contrast to Experiment 1, we found that active tRNS relative to sham tRNS reduced face memory performance in both younger and older adults. We also found that the degree of decline in performance in the active tRNS relative to sham tRNS condition was predicted by baseline ability, with higher performing participants showing the largest decreases in performance. Overall, the results indicate that tRNS to the VLPFC modulates face memory, but that there may be performance and protocol specific moderators of this effect. We discuss these findings in the context of the broader literature showing the importance of individual variation in the outcome of non-invasive brain stimulation intervention approaches. We conclude that while tRNS may have potential as an intervention approach, generalizing from single experiment studies to wide application is risky and caution should be adopted in interpreting findings.

Original languageEnglish (US)
Article number00863
JournalFrontiers in Neuroscience
Volume12
Issue numberNOV
DOIs
StatePublished - Nov 29 2018

Fingerprint

Young Adult
Aptitude
Prefrontal Cortex
Transcranial Direct Current Stimulation
Brain

Keywords

  • Aging
  • Face memory
  • Face recognition
  • Individual differences
  • Transcranial electrical stimulation
  • Transcranial random noise stimulation

Cite this

Using high frequency transcranial random noise stimulation to modulate face memory performance in younger and older adults : Lessons learnt from mixed findings. / Penton, Tegan; Bate, Sarah; Dalrymple, Kirsten; Reed, Thomas; Kelly, Maria; Godovich, Sheina; Tamm, Marin; Duchaine, Bradley; Banissy, Michael J.

In: Frontiers in Neuroscience, Vol. 12, No. NOV, 00863, 29.11.2018.

Research output: Contribution to journalArticle

Penton, Tegan ; Bate, Sarah ; Dalrymple, Kirsten ; Reed, Thomas ; Kelly, Maria ; Godovich, Sheina ; Tamm, Marin ; Duchaine, Bradley ; Banissy, Michael J. / Using high frequency transcranial random noise stimulation to modulate face memory performance in younger and older adults : Lessons learnt from mixed findings. In: Frontiers in Neuroscience. 2018 ; Vol. 12, No. NOV.
@article{fddd2955759b4001baaf4151cfe74047,
title = "Using high frequency transcranial random noise stimulation to modulate face memory performance in younger and older adults: Lessons learnt from mixed findings",
abstract = "High-frequency transcranial random noise stimulation (tRNS) has been shown to improve a range of cognitive and perceptual abilities. Here we sought to examine the effects of a single session of tRNS targeted at the ventrolateral prefrontal cortices (VLPFC) on face memory in younger and older adults. To do so, we conducted three experiments. In Experiment 1, we found that younger adults receiving active tRNS outperformed those receiving sham stimulation (i.e., using a between-participant factor for stimulation condition; Experiment 1). This effect was not observed for object memory (car memory) in younger adults (Experiment 2), indicating that the effect is not a general memory effect. In Experiment 3, we sought to replicate the effects of Experiment 1 using a different design (within-participant factor of stimulation - active or sham tRNS to the same individual) and to extend the study by including older adult participants. In contrast to Experiment 1, we found that active tRNS relative to sham tRNS reduced face memory performance in both younger and older adults. We also found that the degree of decline in performance in the active tRNS relative to sham tRNS condition was predicted by baseline ability, with higher performing participants showing the largest decreases in performance. Overall, the results indicate that tRNS to the VLPFC modulates face memory, but that there may be performance and protocol specific moderators of this effect. We discuss these findings in the context of the broader literature showing the importance of individual variation in the outcome of non-invasive brain stimulation intervention approaches. We conclude that while tRNS may have potential as an intervention approach, generalizing from single experiment studies to wide application is risky and caution should be adopted in interpreting findings.",
keywords = "Aging, Face memory, Face recognition, Individual differences, Transcranial electrical stimulation, Transcranial random noise stimulation",
author = "Tegan Penton and Sarah Bate and Kirsten Dalrymple and Thomas Reed and Maria Kelly and Sheina Godovich and Marin Tamm and Bradley Duchaine and Banissy, {Michael J.}",
year = "2018",
month = "11",
day = "29",
doi = "10.3389/fnins.2018.00863",
language = "English (US)",
volume = "12",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Research Foundation",
number = "NOV",

}

TY - JOUR

T1 - Using high frequency transcranial random noise stimulation to modulate face memory performance in younger and older adults

T2 - Lessons learnt from mixed findings

AU - Penton, Tegan

AU - Bate, Sarah

AU - Dalrymple, Kirsten

AU - Reed, Thomas

AU - Kelly, Maria

AU - Godovich, Sheina

AU - Tamm, Marin

AU - Duchaine, Bradley

AU - Banissy, Michael J.

PY - 2018/11/29

Y1 - 2018/11/29

N2 - High-frequency transcranial random noise stimulation (tRNS) has been shown to improve a range of cognitive and perceptual abilities. Here we sought to examine the effects of a single session of tRNS targeted at the ventrolateral prefrontal cortices (VLPFC) on face memory in younger and older adults. To do so, we conducted three experiments. In Experiment 1, we found that younger adults receiving active tRNS outperformed those receiving sham stimulation (i.e., using a between-participant factor for stimulation condition; Experiment 1). This effect was not observed for object memory (car memory) in younger adults (Experiment 2), indicating that the effect is not a general memory effect. In Experiment 3, we sought to replicate the effects of Experiment 1 using a different design (within-participant factor of stimulation - active or sham tRNS to the same individual) and to extend the study by including older adult participants. In contrast to Experiment 1, we found that active tRNS relative to sham tRNS reduced face memory performance in both younger and older adults. We also found that the degree of decline in performance in the active tRNS relative to sham tRNS condition was predicted by baseline ability, with higher performing participants showing the largest decreases in performance. Overall, the results indicate that tRNS to the VLPFC modulates face memory, but that there may be performance and protocol specific moderators of this effect. We discuss these findings in the context of the broader literature showing the importance of individual variation in the outcome of non-invasive brain stimulation intervention approaches. We conclude that while tRNS may have potential as an intervention approach, generalizing from single experiment studies to wide application is risky and caution should be adopted in interpreting findings.

AB - High-frequency transcranial random noise stimulation (tRNS) has been shown to improve a range of cognitive and perceptual abilities. Here we sought to examine the effects of a single session of tRNS targeted at the ventrolateral prefrontal cortices (VLPFC) on face memory in younger and older adults. To do so, we conducted three experiments. In Experiment 1, we found that younger adults receiving active tRNS outperformed those receiving sham stimulation (i.e., using a between-participant factor for stimulation condition; Experiment 1). This effect was not observed for object memory (car memory) in younger adults (Experiment 2), indicating that the effect is not a general memory effect. In Experiment 3, we sought to replicate the effects of Experiment 1 using a different design (within-participant factor of stimulation - active or sham tRNS to the same individual) and to extend the study by including older adult participants. In contrast to Experiment 1, we found that active tRNS relative to sham tRNS reduced face memory performance in both younger and older adults. We also found that the degree of decline in performance in the active tRNS relative to sham tRNS condition was predicted by baseline ability, with higher performing participants showing the largest decreases in performance. Overall, the results indicate that tRNS to the VLPFC modulates face memory, but that there may be performance and protocol specific moderators of this effect. We discuss these findings in the context of the broader literature showing the importance of individual variation in the outcome of non-invasive brain stimulation intervention approaches. We conclude that while tRNS may have potential as an intervention approach, generalizing from single experiment studies to wide application is risky and caution should be adopted in interpreting findings.

KW - Aging

KW - Face memory

KW - Face recognition

KW - Individual differences

KW - Transcranial electrical stimulation

KW - Transcranial random noise stimulation

UR - http://www.scopus.com/inward/record.url?scp=85057724121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057724121&partnerID=8YFLogxK

U2 - 10.3389/fnins.2018.00863

DO - 10.3389/fnins.2018.00863

M3 - Article

VL - 12

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

IS - NOV

M1 - 00863

ER -