Using fMRI to guide neurosurgery in a combined 1.5 Tesla MR-operating room

H. Liu, W. A. Hall, A. J. Martin, R. E. Maxwell, Chip Truwit

Research output: Contribution to journalConference articlepeer-review


To take advantage of MR-guided surgical procedures performed in a combined MR-OR, we have implemented and validated a practical fMRI scheme for localizing primary motor area and assessing its proximity to a lesion volume. The fMRI scheme consists of a dynamical blood oxygenation level dependent (BOLD) imaging technique and a motor task paradigm. The functional imaging was based on gradient-echo(GE) echo planar imaging (EPI) (TR/TE=3000/50m sec). The task paradigm involves a periodic finger movement in which subject was instructed to tap his/her thumb on the other four fingers sequentially as well as to alternate between the right and left sides. During the task, a dynamical fMRI was performed concurrently covering the volume of interest. By using the fMRI scheme, we have successfully performed ten fMRI examinations immediately prior to surgery in the combined MR-OR on the same surgical table top to localize the eloquent functional area of interests. Also we have developed methods of detrending and presenting fMRI results to neurosurgeons in an intuitive 3-dimensional surface-rendered display format that closely matches the patienthead position underintervention. Representative cases showed that fMRI results helped neurosurgeons making the optimal surgical decisions prior to craniotomy.

Original languageEnglish (US)
Pages (from-to)348-353
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2001
EventMedical Imaging 2001: Physiology and Function from Multidimensional Images - Sandiego, CA, United States
Duration: Feb 18 2001Feb 20 2001


  • BOLD
  • Brain activation
  • Interventional MRI
  • MRI guidance
  • Neurosurgery
  • Primary motor area
  • fMRI


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