Using embryonic stem cells as a model of pancreatic development

Zhaohui Geng, Lucas Chase, Meri T. Firpo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Embryonic stem cells, which can differentiate into insulin-producing cells and express pancreas specific markers during development in vitro, provide a model for studying pancreatic development. Current models of pancreatic development are based on animal models, including zebrafish, chicken and mouse. Genetic manipulations in the mouse have been a major source of information to date.More recently, in vitro differentiation of mouse embryonic stem cells has been used to allow both environmental and genetic manipulation during differentiation.While gene expression during in vitro differentiation appears to reproduce patterns found in vivo, comparison of mouse and human embryonic stem cell differentiation has demonstrated differences between regulation of mouse and human development. In this chapter, we review several studies on ES cell differentiation into insulinproducing cells in vitro and analysis of pancreatic-specific gene expression during differentiation, and discuss the potential of using human ES cells as a model of human pancreatic development.

Original languageEnglish (US)
Title of host publicationStem Cells and Regenerative Medicine
PublisherWorld Scientific Publishing Co.
Pages27-44
Number of pages18
ISBN (Electronic)9789812775771
ISBN (Print)9812775765, 9789812775764
DOIs
StatePublished - Jan 1 2008

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