Using embryonic stem cells as a model of pancreatic development

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Embryonic stem cells, which can differentiate into insulin-producing cells and express pancreas specific markers during development in vitro, provide a model for studying pancreatic development. Current models of pancreatic development are based on animal models, including zebrafish, chicken and mouse. Genetic manipulations in the mouse have been a major source of information to date.More recently, in vitro differentiation of mouse embryonic stem cells has been used to allow both environmental and genetic manipulation during differentiation.While gene expression during in vitro differentiation appears to reproduce patterns found in vivo, comparison of mouse and human embryonic stem cell differentiation has demonstrated differences between regulation of mouse and human development. In this chapter, we review several studies on ES cell differentiation into insulinproducing cells in vitro and analysis of pancreatic-specific gene expression during differentiation, and discuss the potential of using human ES cells as a model of human pancreatic development.

Original languageEnglish (US)
Title of host publicationStem Cells and Regenerative Medicine
PublisherWorld Scientific Publishing Co.
Pages27-44
Number of pages18
ISBN (Print)9789812775771, 9812775765, 9789812775764
DOIs
StatePublished - Jan 1 2008

Fingerprint

Embryonic Stem Cells
Anthralin
In Vitro Techniques
Status Epilepticus
Human Development
Cell Differentiation
Gene Expression
Gene expression
Zebrafish
Pancreas
Chickens
Insulin
Porphobilinogen Synthase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Geng, Z., Chase, L., & Firpo, M. T. (2008). Using embryonic stem cells as a model of pancreatic development. In Stem Cells and Regenerative Medicine (pp. 27-44). World Scientific Publishing Co.. DOI: 10.1142/9789812775771_0002

Using embryonic stem cells as a model of pancreatic development. / Geng, Zhaohui; Chase, Lucas; Firpo, Meri T.

Stem Cells and Regenerative Medicine. World Scientific Publishing Co., 2008. p. 27-44.

Research output: Chapter in Book/Report/Conference proceedingChapter

Geng, Z, Chase, L & Firpo, MT 2008, Using embryonic stem cells as a model of pancreatic development. in Stem Cells and Regenerative Medicine. World Scientific Publishing Co., pp. 27-44. DOI: 10.1142/9789812775771_0002
Geng Z, Chase L, Firpo MT. Using embryonic stem cells as a model of pancreatic development. In Stem Cells and Regenerative Medicine. World Scientific Publishing Co.2008. p. 27-44. Available from, DOI: 10.1142/9789812775771_0002

Geng, Zhaohui; Chase, Lucas; Firpo, Meri T. / Using embryonic stem cells as a model of pancreatic development.

Stem Cells and Regenerative Medicine. World Scientific Publishing Co., 2008. p. 27-44.

Research output: Chapter in Book/Report/Conference proceedingChapter

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