Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics

Matthew K. Breitenstein; Gyorgy J Simon; Euijung Ryu; Sebastian M. Armasu; Richard M. Weinshilboum; Liewei Wang; Jyotishman Pathak

doi:10.3233/978-1-61499-512-8-914

Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics

Matthew K. Breitenstein
, Gyorgy J Simon
, Euijung Ryu
, Sebastian M. Armasu
, Richard M. Weinshilboum
, Liewei Wang
, Jyotishman Pathak

Medicine - General Internal Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Scopus citations

Abstract

Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue.

Original language	English (US)
Title of host publication	Digital Healthcare Empowering Europeans - Proceedings of MIE 2015
Editors	Ronald Cornet, Lacramioara Stoicu-Tivadar, Ronald Cornet, Carlos Luis Parra Calderon, Stig Kjaer Andersen, Alexander Horbst, Mira Hercigonja-Szekeres
Publisher	IOS Press
Pages	914-918
Number of pages	5
ISBN (Electronic)	9781614995111
DOIs	https://doi.org/10.3233/978-1-61499-512-8-914
State	Published - 2015
Event	26th Medical Informatics in Europe Conference, MIE 2015 - Madrid, Spain Duration: May 27 2015 → May 29 2015

Publication series

Name	Studies in Health Technology and Informatics
Volume	210
ISSN (Print)	0926-9630
ISSN (Electronic)	1879-8365

Other

Other	26th Medical Informatics in Europe Conference, MIE 2015
Country/Territory	Spain
City	Madrid
Period	5/27/15 → 5/29/15

Bibliographical note

Publisher Copyright:
© 2015 European Federation for Medical Informatics (EFMI).

Keywords

Biobank
Electronic Health Records
Metformin
Pharmacogenomics
Type 2 Diabetes Mellitus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.3233/978-1-61499-512-8-914

Find It

Find It at U of M Libraries

Cite this

Breitenstein, M. K., Simon, G. J., Ryu, E., Armasu, S. M., Weinshilboum, R. M., Wang, L., & Pathak, J. (2015). Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics. In R. Cornet, L. Stoicu-Tivadar, R. Cornet, C. L. Parra Calderon, S. K. Andersen, A. Horbst, & M. Hercigonja-Szekeres (Eds.), Digital Healthcare Empowering Europeans - Proceedings of MIE 2015 (pp. 914-918). (Studies in Health Technology and Informatics; Vol. 210). IOS Press. https://doi.org/10.3233/978-1-61499-512-8-914

Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics. / Breitenstein, Matthew K.; Simon, Gyorgy J; Ryu, Euijung et al.
Digital Healthcare Empowering Europeans - Proceedings of MIE 2015. ed. / Ronald Cornet; Lacramioara Stoicu-Tivadar; Ronald Cornet; Carlos Luis Parra Calderon; Stig Kjaer Andersen; Alexander Horbst; Mira Hercigonja-Szekeres. IOS Press, 2015. p. 914-918 (Studies in Health Technology and Informatics; Vol. 210).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Breitenstein, MK, Simon, GJ, Ryu, E, Armasu, SM, Weinshilboum, RM, Wang, L & Pathak, J 2015, Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics. in R Cornet, L Stoicu-Tivadar, R Cornet, CL Parra Calderon, SK Andersen, A Horbst & M Hercigonja-Szekeres (eds), Digital Healthcare Empowering Europeans - Proceedings of MIE 2015. Studies in Health Technology and Informatics, vol. 210, IOS Press, pp. 914-918, 26th Medical Informatics in Europe Conference, MIE 2015, Madrid, Spain, 5/27/15. https://doi.org/10.3233/978-1-61499-512-8-914

Breitenstein MK, Simon GJ, Ryu E, Armasu SM, Weinshilboum RM, Wang L et al. Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics. In Cornet R, Stoicu-Tivadar L, Cornet R, Parra Calderon CL, Andersen SK, Horbst A, Hercigonja-Szekeres M, editors, Digital Healthcare Empowering Europeans - Proceedings of MIE 2015. IOS Press. 2015. p. 914-918. (Studies in Health Technology and Informatics). doi: 10.3233/978-1-61499-512-8-914

Breitenstein, Matthew K. ; Simon, Gyorgy J ; Ryu, Euijung et al. / Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics. Digital Healthcare Empowering Europeans - Proceedings of MIE 2015. editor / Ronald Cornet ; Lacramioara Stoicu-Tivadar ; Ronald Cornet ; Carlos Luis Parra Calderon ; Stig Kjaer Andersen ; Alexander Horbst ; Mira Hercigonja-Szekeres. IOS Press, 2015. pp. 914-918 (Studies in Health Technology and Informatics).

@inproceedings{57e1e0ac27bd42549cd5b133f88d7591,

title = "Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics",

abstract = "Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue.",

keywords = "Biobank, Electronic Health Records, Metformin, Pharmacogenomics, Type 2 Diabetes Mellitus",

author = "Breitenstein, \{Matthew K.\} and Simon, \{Gyorgy J\} and Euijung Ryu and Armasu, \{Sebastian M.\} and Weinshilboum, \{Richard M.\} and Liewei Wang and Jyotishman Pathak",

note = "Publisher Copyright: {\textcopyright} 2015 European Federation for Medical Informatics (EFMI).; 26th Medical Informatics in Europe Conference, MIE 2015 ; Conference date: 27-05-2015 Through 29-05-2015",

year = "2015",

doi = "10.3233/978-1-61499-512-8-914",

language = "English (US)",

series = "Studies in Health Technology and Informatics",

publisher = "IOS Press",

pages = "914--918",

editor = "Ronald Cornet and Lacramioara Stoicu-Tivadar and Ronald Cornet and \{Parra Calderon\}, \{Carlos Luis\} and Andersen, \{Stig Kjaer\} and Alexander Horbst and Mira Hercigonja-Szekeres",

booktitle = "Digital Healthcare Empowering Europeans - Proceedings of MIE 2015",

}

TY - GEN

T1 - Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics

AU - Breitenstein, Matthew K.

AU - Simon, Gyorgy J

AU - Ryu, Euijung

AU - Armasu, Sebastian M.

AU - Weinshilboum, Richard M.

AU - Wang, Liewei

AU - Pathak, Jyotishman

PY - 2015

Y1 - 2015

N2 - Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue.

AB - Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue.

KW - Biobank

KW - Electronic Health Records

KW - Metformin

KW - Pharmacogenomics

KW - Type 2 Diabetes Mellitus

UR - https://www.scopus.com/pages/publications/84937485223

UR - https://www.scopus.com/pages/publications/84937485223#tab=citedBy

U2 - 10.3233/978-1-61499-512-8-914

DO - 10.3233/978-1-61499-512-8-914

M3 - Conference contribution

C2 - 25991289

AN - SCOPUS:84937485223

T3 - Studies in Health Technology and Informatics

SP - 914

EP - 918

BT - Digital Healthcare Empowering Europeans - Proceedings of MIE 2015

A2 - Cornet, Ronald

A2 - Stoicu-Tivadar, Lacramioara

A2 - Cornet, Ronald

A2 - Parra Calderon, Carlos Luis

A2 - Andersen, Stig Kjaer

A2 - Horbst, Alexander

A2 - Hercigonja-Szekeres, Mira

PB - IOS Press

T2 - 26th Medical Informatics in Europe Conference, MIE 2015

Y2 - 27 May 2015 through 29 May 2015

ER -

Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics

Abstract

Publication series

Other

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this