Using dates (Phoenix dactylifera l.) to improve energy metabolism in fatigue-induced Sprague Dawley rats

Hana Kadum, Azizah Hamid, Faridah Abas, Nurul Shazini Ramli, Ahmad Haniff Jaafar, Mohd Sabri Pak Dek, Belal J. Muhialdin, Hani Hafeeza Halim, Abdul Karim Sabo Mohammed, Salam A. Ibrahim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Fatigue increases oxidative stress which damages body cells and increases the risk for the development of various chronic diseases. In this study, the anti-fatigue activity of Piyarom date extract was evaluated in fatigue-induced rats using a forced swimming test (FST). Results showed that rats treated with 500 mg/kg BW date extract exhibited enhanced energy production with a highest endurance capacity (632.9±28.7 min). The date-treated rats also had lower blood lactate, indicating efficient energy utilization with lower fatigue as compared to normal and fatigued rats. Moreover, the serum lactate dehydrogenase levels in 250 and 500 mg/kg BW date extracts and caffeine groups were significantly lower compared to the fatigued rats. Creatine kinase activity was the lowest in the group fed with 500 mg/kg BW date extract. The treated rats showed an amelioration of lipid profiles, while the histological study revealed improvement in various organs. Rats treated with 500 mg/kg BW date extract demonstrated an enhancement in energy production and improved energy metabolism which could be due to the presence of bioactive compounds in the dates. Piyarom date extract demonstrated anti-fatigue property and could be used as a functional ingredient in the development of beverages or snacks that address fatigue associated maladies.

Original languageEnglish (US)
Article number100077
JournalFuture Foods
StatePublished - Dec 2021
Externally publishedYes

Bibliographical note

Funding Information:
The authors would like to acknowledge the research grant provided by Universiti Putra Malaysia ( 9541300 ), the Faculty of Food Science and Technology and the Faculty of Medicine and Health Science for the research facilities provided.

Publisher Copyright:
© 2021


  • Anti-fatigue activity
  • Dates
  • Forced swimming test
  • Functional food


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