Using cryo-electron microscopy to determine thermodynamic and elastic properties of membranes

Ryan Van Zanten, Joseph A. Zasadzinski

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Both cryo transmission electron and freeze-fracture microscopy provide the high resolution images necessary to elucidate the structures and size distributions of spontaneous vesicles formed from cationic and anionic surfactant mixtures, lipid and polymer mixtures, and mixed lipid and protein mixtures. From the size distributions and structures, estimates of the elastic and thermodynamic properties of the membrane can be determined to begin to relate molecular properties to bilayer parameters.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalCurrent Opinion in Colloid and Interface Science
Volume10
Issue number5-6
DOIs
StatePublished - Dec 2005

Bibliographical note

Funding Information:
The authors wish to thank Hee-Tae Jung and Bret Coldren at UCSB, Eric Kaler and his group at the University of Delaware for ongoing collaborations, and M. Almgren and T. Zemb for generous use of their results on catanionic vesicles. This work was supported by National Science Foundation Grant #CTS-0436124 and the Petroleum Research Foundation Grant #41016-AC7.

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