TY - JOUR
T1 - Using Big Data Analytics to Advance Precision Radiation Oncology
AU - McNutt, Todd R.
AU - Benedict, Stanley H.
AU - Low, Daniel A.
AU - Moore, Kevin
AU - Shpitser, Ilya
AU - Jiang, Wei
AU - Lakshminarayanan, Pranav
AU - Cheng, Zhi
AU - Han, Peijin
AU - Hui, Xuan
AU - Nakatsugawa, Minoru
AU - Lee, Junghoon
AU - Moore, Joseph A.
AU - Robertson, Scott P.
AU - Shah, Veeraj
AU - Taylor, Russ
AU - Quon, Harry
AU - Wong, John
AU - DeWeese, Theodore
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Big clinical data analytics as a primary component of precision medicine is discussed, identifying where these emerging tools fit in the spectrum of genomics and radiomics research. A learning health system (LHS) is conceptualized that uses clinically acquired data with machine learning to advance the initiatives of precision medicine. The LHS is comprehensive and can be used for clinical decision support, discovery, and hypothesis derivation. These developing uses can positively impact the ultimate management and therapeutic course for patients. The conceptual model for each use of clinical data, however, is different, and an overview of the implications is discussed. With advancements in technologies and culture to improve the efficiency, accuracy, and breadth of measurements of the patient condition, the concept of an LHS may be realized in precision radiation therapy.
AB - Big clinical data analytics as a primary component of precision medicine is discussed, identifying where these emerging tools fit in the spectrum of genomics and radiomics research. A learning health system (LHS) is conceptualized that uses clinically acquired data with machine learning to advance the initiatives of precision medicine. The LHS is comprehensive and can be used for clinical decision support, discovery, and hypothesis derivation. These developing uses can positively impact the ultimate management and therapeutic course for patients. The conceptual model for each use of clinical data, however, is different, and an overview of the implications is discussed. With advancements in technologies and culture to improve the efficiency, accuracy, and breadth of measurements of the patient condition, the concept of an LHS may be realized in precision radiation therapy.
UR - http://www.scopus.com/inward/record.url?scp=85046378660&partnerID=8YFLogxK
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U2 - 10.1016/j.ijrobp.2018.02.028
DO - 10.1016/j.ijrobp.2018.02.028
M3 - Article
C2 - 29726357
AN - SCOPUS:85046378660
SN - 0360-3016
VL - 101
SP - 285
EP - 291
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 2
ER -