Usefulness of Ventricular Premature Complexes to Predict Coronary Heart Disease Events and Mortality (from the Atherosclerosis Risk In Communities Cohort)

Mark W. Massing, Ross J. Simpson, Pentti M. Rautaharju, Pamela J Schreiner, Richard Crow, Gerardo Heiss

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

The clinical relevance of ventricular premature complexes (VPCs) in apparently healthy patients is not clear and is typically not considered when evaluating risk. We conducted a prospective longitudinal study of the population-based Atherosclerosis Risk In Communities (ARIC) study of 15,070 Caucasians and African-Americans, 45 to 64 years of age, to assess the risks of coronary heart disease (CHD) events and mortality associated with VPCs among participants with and without prevalent CHD at baseline. VPCs on a single 2-minute electrocardiogram were identified in 940 participants (6.2%). After a follow-up of >10 years, 1,762 participants died, with 366 deaths related to CHD, and 1,736 had cardiac events. The percentage of participants with CHD mortality was >3 times greater for those with VPCs compared with those without VPCs. After controlling for cardiovascular risk factors and therapy with proportional hazards regression, participants with VPCs were >2 times as likely to die due to CHD than were those without VPCs. Increased risk was found for participants with and without baseline CHD. In conclusion, a clinical finding of VPCs on electrocardiography of even apparently healthy patients may warrant a heightened awareness of and attention to cardiovascular risk assessment and management.

Original languageEnglish (US)
Pages (from-to)1609-1612
Number of pages4
JournalAmerican Journal of Cardiology
Volume98
Issue number12
DOIs
StatePublished - Dec 15 2006

Bibliographical note

Funding Information:
The Atherosclerosis Risk In Communities Study is carried out as a collaborative study supported by Contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland. This research was supported by Contracts N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022 from the National Heart, Lung, and Blood Institute. Further support for Dr. Massing included a National Research Award Grant 5-T32-HL007055 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

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