Several scaffolds having two reactive points and anchored to a solid support were prepared. These structures can display a wide range of pendant functionalities to give libraries of structurally diverse substances which can be used to search for new lead compounds and to achieve their subsequent optimization in a medicinal chemistry program. The scaffolds are based upon diketopiperazine-, cis-aminoproline-, hydrazine-, and alkylenediamine-resins, which contain in all cases two amino functions blocked selectively with orthogonally removable protecting groups.
|Original language||English (US)|
|Number of pages||8|
|Journal||Reactive and Functional Polymers|
|State||Published - Jul 15 1999|
|Event||Proceedings of the 1998 8th International Conference on Polymer-Based Technology (POC '98) - Ma'ale Hachamisha, Isr|
Duration: Jun 29 1998 → Jul 2 1998
Bibliographical noteFunding Information:
Research at Barcelona was supported by CICYT (PB96-1490) and Generalitat de Catalunya [Grup Consolidat (1995SGR 494) i Centre de Referència en Biotecnologia] and at Minnesota by the National Institutes of Health (Grant GM 42722). We are grateful to the Conde de Barcelona Foundation, Spain, for a fellowship to J.A., and to the University of Barcelona for a predoctoral fellowship to M.d.F.