Useful scaffolds and handles for creating diversity in the preparation of chemical libraries

Miriam Royo, Montserrat Del Fresno, Ariadna Frieden, Wim Van Den Nest, Marina Sanseverino, Jordi Alsina, Steven A. Kates, George Barany, Fernando Albericio

Research output: Contribution to journalConference articlepeer-review

11 Scopus citations

Abstract

Several scaffolds having two reactive points and anchored to a solid support were prepared. These structures can display a wide range of pendant functionalities to give libraries of structurally diverse substances which can be used to search for new lead compounds and to achieve their subsequent optimization in a medicinal chemistry program. The scaffolds are based upon diketopiperazine-, cis-aminoproline-, hydrazine-, and alkylenediamine-resins, which contain in all cases two amino functions blocked selectively with orthogonally removable protecting groups.

Original languageEnglish (US)
Pages (from-to)103-110
Number of pages8
JournalReactive and Functional Polymers
Volume41
Issue number1
DOIs
StatePublished - Jul 15 1999
EventProceedings of the 1998 8th International Conference on Polymer-Based Technology (POC '98) - Ma'ale Hachamisha, Isr
Duration: Jun 29 1998Jul 2 1998

Bibliographical note

Funding Information:
Research at Barcelona was supported by CICYT (PB96-1490) and Generalitat de Catalunya [Grup Consolidat (1995SGR 494) i Centre de Referència en Biotecnologia] and at Minnesota by the National Institutes of Health (Grant GM 42722). We are grateful to the Conde de Barcelona Foundation, Spain, for a fellowship to J.A., and to the University of Barcelona for a predoctoral fellowship to M.d.F.

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