Use of the deconvolution principle in the estimation of absorption and pre-systemic intestinal elimination of drugs

Yazdi K. Pithavala, Inmaculada Soria, Cheryl L. Zimmerman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The deconvolution principle was used to evaluate the extent of absorption and first-pass elimination of selected drugs. In the first example, deconvolution of the portal blood profiles of etretinate (ET, a synthetic retinoid) indicated that there was significant gut-wall conversion of ET to acitretin (ETA, the primary metabolite of ET) during a 60-min intestinal perfusion of ET. In the second example, deconvolution was used to confirm that the extent of carbovir disappearing from the gastrointestinal lumen was matched by the extent of carbovir appearance in the portal blood. Thus, deconvolution has several important applications in the study of absorption and intestinal first-pass metabolism.

Original languageEnglish (US)
Pages (from-to)1260-1265
Number of pages6
JournalDrug Metabolism and Disposition
Volume25
Issue number11
StatePublished - Nov 1997

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