Use of technetium-99m methylene diphosphonate and gallium-67 citrate scans after intraarticular injection of staphylococcus aureus into knee joints of rabbits with chronic antigen-induced arthritis

Maren L. Mahowald, John R. Raskind, Lance Peterson, Dale Gerding, Donald A. Raddatz, Rex Shafer, Donald A. Raddatz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Numerous clinical studies have questioned the ability of radionuclide scans to differentiate septic from aseptic joint inflammation. A clinical study may not be able to document an underlying disease process or duration of infection and, thus, may make conclusions about the accuracy of scan interpretations open to debate. In this study, the Dumonde- Glynn model of antigen-induced arthritis in rabbits was used as the experimental model to study technetium and gallium scans in Staphylococcus aureus infection of arthritic and normal joints. Galium scans were negative in normal rabbits, usually negative in antigen-induced arthritis, but positive in septic arthritis. The bone scan was usually negative in early infection but positive in late septic arthritis, a finding reflecting greater penetration of bacteria into subchondral bone because of the underlying inflammatory process.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalJournal of Infectious Diseases
Volume154
Issue number2
DOIs
StatePublished - Aug 1986

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