Use of Skin Biopsy in the Diagnosis of Small Fibre Neuropathy

G. Lauria, S. T. Hsieh, O. Johansson, W. R. Kennedy, J. M. Leger, S. I. Mellgren, M. Nolano, I. S.J. Merkies, M. Polydefkis, A. G. Smith, C. Sommer, J. Valls-Solé

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationEuropean Handbook of Neurological Management
Subtitle of host publicationSecond Edition
Number of pages10
ISBN (Print)9781405185332
StatePublished - Sep 6 2010


  • Clinical applications of skin biopsy in SFN-using similar inclusion criteria for patients
  • Correlation with small fibre-related evoked potentials
  • Data extraction, carried out-and compared among each member of task force
  • Document, written under auspices of European Federation of the Neurological Societies (EFNS)
  • IENF morphometry and measurement reliability
  • Less invasive sampling method-removal of epidermis alone by applying a suction capsule to skin
  • Normative reference values-Bright-field immunohistochemistry
  • Perform skin biopsy and choice of biopsy location
  • Quantification of sweat gland innervation
  • Skin biopsy use-in diagnosis of small fibre neuropathy

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