Use of Short-wave Blue Fundus Autofluorescence to Detect and Monitor Acute Regional Outer Retinopathy in Punctate Inner Choroidopathy

Caroline L. Minkus, Jeremy A. Lavine, Jennifer Lee, Dimitra Skondra, Debra A. Goldstein

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To describe the utility of fundus autofluorescence (FAF) for detection and monitoring of acute regional outer retinopathy in punctate inner choroidopathy (PIC). Design: Multimodal imaging case series. Methods: Patients with PIC and acute regional hyperautofluorescence were identified. Multimodal imaging, treatment, and clinical course were reviewed. Results: Six eyes of five patients were included (5 women, mean age 39 years, range 28–69). All endorsed new symptoms. Short-wave blue FAF revealed regional hyperautofluorescence in the symptomatic eye, corresponding to ellipsoid zone (EZ) loss on optical coherence tomography (OCT). All patients were treated with local or systemic corticosteroids or immunosuppression, with resolution of symptoms and acute imaging abnormalities. Conclusions: Symptomatic acute regional outer retinopathy in PIC, manifesting as hyperautofluorescence and EZ loss, is easily identifiable using widefield FAF imaging. Treatment resulted in resolution of symptoms and imaging findings in our cohort, and should be considered in this patient population.

Original languageEnglish (US)
JournalOcular Immunology and Inflammation
DOIs
StateAccepted/In press - 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.

Keywords

  • acute regional outer retinopathy
  • ellipsoid zone
  • Fundus autofluorescence
  • punctate inner choroidopathy
  • treatment

PubMed: MeSH publication types

  • Journal Article

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