Use of recombinant human follicle-stimulating hormone for in vitro fertilization-embryo transfer after severe systemic immunoglobulin E-mediated reaction to urofollitropin

W. R. Phipps, D. Holden, R. K. Sheehan

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Objective: To report the successful use of recombinant human FSH in a patient with a history of a severe systemic immunoglobulin E (IgE)-mediated reaction to urofollitropin. Setting: University hospital. Patient: A 38- year-old infertility patient who had experienced a whole-body rash with hives, tachycardia, fever, and other symptoms after urofollitropin administration, with confirmation of IgE-mediated sensitivity to urofollitropin by intradermal skin testing. Intervention: In vitro fertilization-ET after the use of recombinant human FSH to stimulate ovarian follicular development. Results: Establishment of a clinical pregnancy. Conclusions: Our case provides evidence for the involvement of nongonadotropin proteins as the direct cause of some adverse reactions from conventional urine-derived human FSH preparations.

Original languageEnglish (US)
Pages (from-to)148-150
Number of pages3
JournalFertility and Sterility
Volume66
Issue number1
DOIs
StatePublished - Jan 1 1996

Keywords

  • Allergic reactions
  • case report
  • in vitro fertilization-embryo transfer
  • recombinant human FSH
  • urofollitropin

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