Use of recombinant human follicle-stimulating hormone for in vitro fertilization-embryo transfer after severe systemic immunoglobulin E-mediated reaction to urofollitropin

William R. Phipps, Dawn Holden, Richard K. Sheehan

Research output: Contribution to journalArticle

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Abstract

Objective: To report the successful use of recombinant human FSH in a patient with a history of a severe systemic immunoglobulin E (IgE)-mediated reaction to urofollitropin. Setting: University hospital. Patient(s): A 38- year-old infertility patient who had experienced a whole-body rash with hives, tachycardia, fever, and other symptoms after urofollitropin administration, with confirmation of IgE-mediated sensitivity to urofollitropin by intradermal skin testing. Intervention(s): In vitro fertilization-ET after the use of recombinant human FSH to stimulate ovarian follicular development. Result(s): Establishment of a clinical pregnancy. Conclusion(s): Our case provides evidence for the involvement of nongonadotropin proteins as the direct cause of some adverse reactions from conventional urine-derived human FSH preparations.

Original languageEnglish (US)
Pages (from-to)69S-71S
JournalFertility and Sterility
Volume69
Issue number3 SUPPL. 2
DOIs
StatePublished - Mar 1998

Keywords

  • Allergic reactions
  • Case report
  • In vitro fertilization-embryo transfer
  • Recombinant human FSH
  • Urofollitropin

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