Use of recombinant factor VIIa (rFVIIa) to control intraoperative bleeding in pediatric brain tumor patients

Margaret Heisel, Mahmoud G Nagib, L. Madsen, M. Alshiekh, A. Bendel

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Surgical bleeding during the resection of brain tumors in children may be related to tumor vascularity, pathology, and location. Despite improvements in neurosurgical technique, neuroanesthesia, and blood product replacement, bleeding can be life-threatening in these surgeries. We report eight pediatric patients in whom recombinant factor VIIa (rFVIIa) was used to control intraoperative bleeding during surgical resection of pediatric brain tumors. rFVIIa should be considered as a method to control intraoperative bleeding that is unresponsive to conventional interventions. Additional studies are needed to determine optimal patient selection and drug dosing, efficacy and safety.

Original languageEnglish (US)
Pages (from-to)703-705
Number of pages3
JournalPediatric Blood and Cancer
Volume43
Issue number6
DOIs
StatePublished - Nov 1 2004

Keywords

  • Pediatric
  • RFVIIa
  • Recombinant factor VIIa
  • Surgical hemostasis

Fingerprint Dive into the research topics of 'Use of recombinant factor VIIa (rFVIIa) to control intraoperative bleeding in pediatric brain tumor patients'. Together they form a unique fingerprint.

Cite this