Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus

Michael Mullerad; David P. Eisenberg; Timothy J. Akhurst; Prasad S. Adusumilli; Christopher C. Riedl; Amit Bhargava; Mithat Gonen; Ronald Finn; Peter T. Scardino; Yuman Fong

doi:10.1007/s11307-005-0028-x

Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus

Michael Mullerad
, David P. Eisenberg
, Timothy J. Akhurst
, Prasad S. Adusumilli
, Christopher C. Riedl
, Amit Bhargava
, Mithat Gonen
, Ronald Finn
, Peter T. Scardino
, Yuman Fong

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-18]fluoro-d-glucose (FDG) uptake by positron emission tomography (PET) is a sensitive method of detecting altered cellular metabolism involved in cancer therapy. We therefore hypothesized that FDG-PET can predict tumor response to oncolytic HSV therapy. In this study, androgen increased cell kill (74%) in vitro and enhanced viral yield (2.4-fold) in vivo following HSV therapy. This enhanced efficacy was predicted by high FDG accumulation in intact animals compared to low FDG uptake following orchiectomy (p = 0.002). This proof-of-concept study provides the mechanistic basis for selecting patients for targeted oncolytic viral therapy by means of a noninvasive molecular imaging method in the treatment of prostate cancer.

Original language	English (US)
Pages (from-to)	30-35
Number of pages	6
Journal	Molecular Imaging and Biology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1007/s11307-005-0028-x
State	Published - Jan 2006
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported in part by grant ROI CA 75416 from the National Institutes of Health, grant IMG0402501 from the Susan G. Komen Foundation, grant R25-CA96945 from the National Cancer Institute, and grant BC024118 from the US Army. The radiotracer was prepared in a facility constructed with support from Research Facilities Improvement Program Grant number C06 RR-11192.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Fluorodeoxyglucose
Herpes virus
Hormonal therapy
Prediction

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10.1007/s11307-005-0028-x

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title = "Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus",

abstract = "Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-18]fluoro-d-glucose (FDG) uptake by positron emission tomography (PET) is a sensitive method of detecting altered cellular metabolism involved in cancer therapy. We therefore hypothesized that FDG-PET can predict tumor response to oncolytic HSV therapy. In this study, androgen increased cell kill (74\%) in vitro and enhanced viral yield (2.4-fold) in vivo following HSV therapy. This enhanced efficacy was predicted by high FDG accumulation in intact animals compared to low FDG uptake following orchiectomy (p = 0.002). This proof-of-concept study provides the mechanistic basis for selecting patients for targeted oncolytic viral therapy by means of a noninvasive molecular imaging method in the treatment of prostate cancer.",

keywords = "Fluorodeoxyglucose, Herpes virus, Hormonal therapy, Prediction",

author = "Michael Mullerad and Eisenberg, \{David P.\} and Akhurst, \{Timothy J.\} and Adusumilli, \{Prasad S.\} and Riedl, \{Christopher C.\} and Amit Bhargava and Mithat Gonen and Ronald Finn and Scardino, \{Peter T.\} and Yuman Fong",

note = "Funding Information: This study was supported in part by grant ROI CA 75416 from the National Institutes of Health, grant IMG0402501 from the Susan G. Komen Foundation, grant R25-CA96945 from the National Cancer Institute, and grant BC024118 from the US Army. The radiotracer was prepared in a facility constructed with support from Research Facilities Improvement Program Grant number C06 RR-11192.",

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doi = "10.1007/s11307-005-0028-x",

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AU - Akhurst, Timothy J.

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AU - Riedl, Christopher C.

AU - Bhargava, Amit

AU - Gonen, Mithat

AU - Finn, Ronald

AU - Scardino, Peter T.

AU - Fong, Yuman

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PY - 2006/1

Y1 - 2006/1

N2 - Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-18]fluoro-d-glucose (FDG) uptake by positron emission tomography (PET) is a sensitive method of detecting altered cellular metabolism involved in cancer therapy. We therefore hypothesized that FDG-PET can predict tumor response to oncolytic HSV therapy. In this study, androgen increased cell kill (74%) in vitro and enhanced viral yield (2.4-fold) in vivo following HSV therapy. This enhanced efficacy was predicted by high FDG accumulation in intact animals compared to low FDG uptake following orchiectomy (p = 0.002). This proof-of-concept study provides the mechanistic basis for selecting patients for targeted oncolytic viral therapy by means of a noninvasive molecular imaging method in the treatment of prostate cancer.

AB - Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-18]fluoro-d-glucose (FDG) uptake by positron emission tomography (PET) is a sensitive method of detecting altered cellular metabolism involved in cancer therapy. We therefore hypothesized that FDG-PET can predict tumor response to oncolytic HSV therapy. In this study, androgen increased cell kill (74%) in vitro and enhanced viral yield (2.4-fold) in vivo following HSV therapy. This enhanced efficacy was predicted by high FDG accumulation in intact animals compared to low FDG uptake following orchiectomy (p = 0.002). This proof-of-concept study provides the mechanistic basis for selecting patients for targeted oncolytic viral therapy by means of a noninvasive molecular imaging method in the treatment of prostate cancer.

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KW - Herpes virus

KW - Hormonal therapy

KW - Prediction

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Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus

Abstract

Bibliographical note

UN SDGs

Keywords

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