Abstract
This research discusses the use of high-resolution optical mapping technique to quantify electrophysiological characteristics of engineered heart tissues (EHTs) that can be used to assess their maturation. Specifically, this study utilizes two electrophysiological parameters: maximum derivative of voltage over time (dv/dt max) and activation time (AT) to the end of assessing EHT functionality. We also investigated the importance of removing noise and artifacts and applying different binary masks to optimize these parameters. Finally, we compare dv/dt max and AT between EHT and murine adult cardiac tissue and demonstrated the sensitivity of these parameters in detecting the electrophysiological characteristics of both primary and engineered tissues.
| Original language | English (US) |
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| Title of host publication | 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024 - Proceedings |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| ISBN (Electronic) | 9798350371499 |
| DOIs | |
| State | Published - 2024 |
| Event | 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024 - Orlando, United States Duration: Jul 15 2024 → Jul 19 2024 |
Publication series
| Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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| ISSN (Print) | 1557-170X |
Conference
| Conference | 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024 |
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| Country/Territory | United States |
| City | Orlando |
| Period | 7/15/24 → 7/19/24 |
Bibliographical note
Publisher Copyright:© 2024 IEEE.
Keywords
- Activation Time
- Conduction Velocity
- Engineered Heart Tissues (EHTs)
- Optical Mapping