Use of mucosal immunization with porcine zona pellucida (PZP) in mice and rabbits

Brent J. Martin, Mark A. Suckow, William R. Wolter, Thomas Berger, John W. Turner

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Rabbits (Oryctolagus cuniculus) and two strains of mice (Mus musculus, one inbred and one outbred) were immunized against porcine zona pellucida (PZP) antigen. Alginate microspheres or cholera toxin B were used alone or in combination when mucosal immunization routes were used. Serum antibody responses and fertility were assessed. Neither rabbit or mouse groups immunized by mucosal routes generated significant antibody responses to PZP as compared to parenteral immunization (ANOVA, P > 0.05). The study shows that porcine zona pellucida is not an effective mucosal antigen in small mammals.

Original languageEnglish (US)
Pages (from-to)372-378
Number of pages7
JournalAnimal reproduction science
Volume93
Issue number3-4
DOIs
StatePublished - Jul 1 2006

Keywords

  • Alginate microsphere
  • Mouse
  • Mucosal immunity
  • PZP
  • Porcine zona pellucida
  • Rabbit

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