Use of megadoses of vitamins with minerals in Down syndrome

George F. Smith, Donna Spiker, Carol P. Peterson, Dante Cicchetti, Parvin Justine

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


To evaluate the effects of megadoses of vitamins with minerals on the cognitive intelligence of children with Down syndrome, a two-group double-blind clinical trial was carried out with 56 school-aged children with Down syndrome. Children were evaluated at baseline, 4 months, and 8 months with a battery of standard psychologic tests, physical examinations, and blood tests. The two groups, which were well-matched is cognitive intelligence and other important subject characteristics at baseline, were not significantly different in intelligence and other test scores at the 4- or 8-month test periods. The particular megadoses of vitamins with minerals used in the study did not produce increased intelligence in the study population.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalThe Journal of pediatrics
Issue number2
StatePublished - Aug 1984
Externally publishedYes

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