Use of megadoses of vitamins with minerals in Down syndrome

George F. Smith, Donna Spiker, Carol P. Peterson, Dante Cicchetti, Parvin Justine

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


To evaluate the effects of megadoses of vitamins with minerals on the cognitive intelligence of children with Down syndrome, a two-group double-blind clinical trial was carried out with 56 school-aged children with Down syndrome. Children were evaluated at baseline, 4 months, and 8 months with a battery of standard psychologic tests, physical examinations, and blood tests. The two groups, which were well-matched is cognitive intelligence and other important subject characteristics at baseline, were not significantly different in intelligence and other test scores at the 4- or 8-month test periods. The particular megadoses of vitamins with minerals used in the study did not produce increased intelligence in the study population.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalThe Journal of pediatrics
Issue number2
StatePublished - Aug 1984
Externally publishedYes

Bibliographical note

Funding Information:
From the Department of Pediatrics, Illinois Masonic Medical Center; the Department of Psychiatry. Child Psychiatry Clinic, University of Chicago; the Department of Psychology and Social Relations, Harvard University; and the Departments of Pediatrics and Biochemistry. University of Illinois at Chicago. Supported by grants from the National Association for Down Syndrome (Chicago) and the Foundation for Nutritional Advancement. Submitted for publication Dec. 30, 1983; accepted Feb. 17, 1984. Reprint requests: George F. Smith, M.D., Department of Pediatrics, Illinois Masonic Medical Center, 836 Wellington Ave., Chicago, IL 60657.


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