Use of magnetic resonance spectroscopy for in vivo evaluation of high- energy phosphate metabolism in normal and abnormal myocardium

Jianyi Zhang; Kamil Ugurbil; Arthur H.L. From; Robert J. Bache

doi:10.3109/10976640009148670

Use of magnetic resonance spectroscopy for in vivo evaluation of high- energy phosphate metabolism in normal and abnormal myocardium

Jianyi Zhang, Kamil Ugurbil, Arthur H.L. From, Robert J. Bache

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

³¹P- and ¹H-nuclear magnetic resonance spectroscopy (MRS) are powerful tools for studying myocardial energy metabolism. The purpose of this review is to illustrate how these MRS techniques can be used to study complex bioenergetic issues in normal and abnormal in vivo myocardium. The results provide insight into the energetic alterations present in remodeled and hypertrophied myocardium. A detailed understanding of energy metabolism in normal and abnormal myocardium may point the way to improved preventive, diagnostic, and therapeutic modalities for left ventricular dysfunction.

Original language	English (US)
Pages (from-to)	23-32
Number of pages	10
Journal	Journal of Cardiovascular Magnetic Resonance
Volume	2
Issue number	1
DOIs	https://doi.org/10.3109/10976640009148670
State	Published - 2000

Keywords

Deoxymyoglobin
High-energy phosphates
Left ventricular hypertrophy
Left ventricular remodeling
Myocardial ischemia

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10.3109/10976640009148670

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abstract = "31P- and 1H-nuclear magnetic resonance spectroscopy (MRS) are powerful tools for studying myocardial energy metabolism. The purpose of this review is to illustrate how these MRS techniques can be used to study complex bioenergetic issues in normal and abnormal in vivo myocardium. The results provide insight into the energetic alterations present in remodeled and hypertrophied myocardium. A detailed understanding of energy metabolism in normal and abnormal myocardium may point the way to improved preventive, diagnostic, and therapeutic modalities for left ventricular dysfunction.",

keywords = "Deoxymyoglobin, High-energy phosphates, Left ventricular hypertrophy, Left ventricular remodeling, Myocardial ischemia",

author = "Jianyi Zhang and Kamil Ugurbil and From, {Arthur H.L.} and Bache, {Robert J.}",

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AU - Zhang, Jianyi

AU - Ugurbil, Kamil

AU - From, Arthur H.L.

AU - Bache, Robert J.

PY - 2000

Y1 - 2000

N2 - 31P- and 1H-nuclear magnetic resonance spectroscopy (MRS) are powerful tools for studying myocardial energy metabolism. The purpose of this review is to illustrate how these MRS techniques can be used to study complex bioenergetic issues in normal and abnormal in vivo myocardium. The results provide insight into the energetic alterations present in remodeled and hypertrophied myocardium. A detailed understanding of energy metabolism in normal and abnormal myocardium may point the way to improved preventive, diagnostic, and therapeutic modalities for left ventricular dysfunction.

AB - 31P- and 1H-nuclear magnetic resonance spectroscopy (MRS) are powerful tools for studying myocardial energy metabolism. The purpose of this review is to illustrate how these MRS techniques can be used to study complex bioenergetic issues in normal and abnormal in vivo myocardium. The results provide insight into the energetic alterations present in remodeled and hypertrophied myocardium. A detailed understanding of energy metabolism in normal and abnormal myocardium may point the way to improved preventive, diagnostic, and therapeutic modalities for left ventricular dysfunction.

KW - Deoxymyoglobin

KW - High-energy phosphates

KW - Left ventricular hypertrophy

KW - Left ventricular remodeling

KW - Myocardial ischemia

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Use of magnetic resonance spectroscopy for in vivo evaluation of high- energy phosphate metabolism in normal and abnormal myocardium

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