Use of high-resolution MRI for investigation of fluid flow and global permeability in a material with interconnected porosity

Pascal Swider, Mark Conroy, Annaïg Pédrono, Dominique Ambard, Sue Mantell, Kjeld Søballe, Joan E. Bechtold

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

We present a multi-scale experimental approach designed to improve the investigation of both localized and global fluid flow in biomaterials with randomly interconnected porosity. Coralline hydroxyapatite (ProOsteon 500 from Interpore-Cross®), having a relatively well-defined porosity, was used as an in vitro model of typical bone architecture. Axial fluid velocity profiles within the pores of a cylindrical hydroxyapatite sample were characterized using high-resolution MRI in conjunction with the measurement of global flow and associated permeability based on the Darcy-type relationship. Assuming Newtonian fluid behaviour, image analysis permitted computation of local porosity, intra-pore fluid shear, and visualization of flow heterogeneity within the sample. These results may benefit applications in biomaterials for the evaluation of factors influencing bony incorporation in porous scaffolds and on porous implant and bone surfaces. Normal and diseased biological tissues are also clinical relevant applications.

Original languageEnglish (US)
Pages (from-to)2112-2118
Number of pages7
JournalJournal of Biomechanics
Volume40
Issue number9
DOIs
StatePublished - 2007

Keywords

  • Bone substitute
  • Fluid velocity
  • High-resolution MR
  • Implant fixation
  • Permeability

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