Use of dupilumab for atopic dermatitis in young transplant patients—A case series of 3 patients

Maritza V. Steele; Rachit Gupta; Sheilagh Maguiness; Christina Boull

doi:10.1111/pde.15280

Use of dupilumab for atopic dermatitis in young transplant patients—A case series of 3 patients

Maritza V. Steele, Rachit Gupta, Sheilagh Maguiness, Christina Boull

Dermatology

Research output: Contribution to journal › Article › peer-review

Abstract

Patients who undergo solid organ transplantation are at an increased risk of developing atopic dermatitis, potentially due to long-term use of calcineurin inhibitors which results in a shift towards the Th2 immune response. The effectiveness and safety of dupilumab for atopic dermatitis in posttransplant patients is not established. Previous reports of dupilumab use in posttransplant patients have been in adult patients. In this series, we report three young posttransplant patients treated successfully with dupilumab.

Original language	English (US)
Journal	Pediatric Dermatology
DOIs	https://doi.org/10.1111/pde.15280
State	Accepted/In press - 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Pediatric Dermatology published by Wiley Periodicals LLC.

Keywords

auto-islet cell transplantation
dupilumab
immunosuppression
renal transplant
transplant
transplant rejection

Publisher link

10.1111/pde.15280

Cite this

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title = "Use of dupilumab for atopic dermatitis in young transplant patients—A case series of 3 patients",

abstract = "Patients who undergo solid organ transplantation are at an increased risk of developing atopic dermatitis, potentially due to long-term use of calcineurin inhibitors which results in a shift towards the Th2 immune response. The effectiveness and safety of dupilumab for atopic dermatitis in posttransplant patients is not established. Previous reports of dupilumab use in posttransplant patients have been in adult patients. In this series, we report three young posttransplant patients treated successfully with dupilumab.",

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doi = "10.1111/pde.15280",

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AU - Maguiness, Sheilagh

AU - Boull, Christina

PY - 2023

Y1 - 2023

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AB - Patients who undergo solid organ transplantation are at an increased risk of developing atopic dermatitis, potentially due to long-term use of calcineurin inhibitors which results in a shift towards the Th2 immune response. The effectiveness and safety of dupilumab for atopic dermatitis in posttransplant patients is not established. Previous reports of dupilumab use in posttransplant patients have been in adult patients. In this series, we report three young posttransplant patients treated successfully with dupilumab.

KW - auto-islet cell transplantation

KW - dupilumab

KW - immunosuppression

KW - renal transplant

KW - transplant

KW - transplant rejection

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ER -

Use of dupilumab for atopic dermatitis in young transplant patients—A case series of 3 patients

Abstract

Bibliographical note

Keywords

Publisher link

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