Use of DNA probes from the 5′ flanking region of the HLA-B gene to examine polymorphism at the HLA-B locus

Karyn Steere; Beth Sidwell; Robin Leach; Francis E. Ward; Joel D. Taurog; Harry T. Orr

doi:10.1016/0198-8859(86)90042-X

Use of DNA probes from the 5′ flanking region of the HLA-B gene to examine polymorphism at the HLA-B locus

Karyn Steere, Beth Sidwell, Robin Leach, Francis E. Ward, Joel D. Taurog, Harry T. Orr

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Two DNA probes isolated from the region 5′ to the HLA-B gene are described. One of these, pCH6, detects a TaqI polymorphism which is correlated with serological alleles of HLA-B. Both probes are used to show a high level of DNA sequence homology between the 5′ flanking region of HLA-B and HLA-C.

Original language	English (US)
Pages (from-to)	137-147
Number of pages	11
Journal	Human Immunology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0198-8859(86)90042-X
State	Published - Jun 1986

Bibliographical note

Funding Information:
Supported by NIH Grants AI 18124 (HTO), AM 34502 (JDT) agrant from the Minnesota Medical Foundation and a grant from the Minnesota Chapter of the Arthritis Foundation. We thank Drs. Bev Koller and Dan Geraghty for making available HLA-B and HLA-C containing cosmids prior to publication.

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title = "Use of DNA probes from the 5′ flanking region of the HLA-B gene to examine polymorphism at the HLA-B locus",

abstract = "Two DNA probes isolated from the region 5′ to the HLA-B gene are described. One of these, pCH6, detects a TaqI polymorphism which is correlated with serological alleles of HLA-B. Both probes are used to show a high level of DNA sequence homology between the 5′ flanking region of HLA-B and HLA-C.",

author = "Karyn Steere and Beth Sidwell and Robin Leach and Ward, {Francis E.} and Taurog, {Joel D.} and Orr, {Harry T.}",

note = "Funding Information: Supported by NIH Grants AI 18124 (HTO), AM 34502 (JDT) agrant from the Minnesota Medical Foundation and a grant from the Minnesota Chapter of the Arthritis Foundation. We thank Drs. Bev Koller and Dan Geraghty for making available HLA-B and HLA-C containing cosmids prior to publication.",

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T1 - Use of DNA probes from the 5′ flanking region of the HLA-B gene to examine polymorphism at the HLA-B locus

AU - Steere, Karyn

AU - Sidwell, Beth

AU - Leach, Robin

AU - Ward, Francis E.

AU - Taurog, Joel D.

AU - Orr, Harry T.

N1 - Funding Information: Supported by NIH Grants AI 18124 (HTO), AM 34502 (JDT) agrant from the Minnesota Medical Foundation and a grant from the Minnesota Chapter of the Arthritis Foundation. We thank Drs. Bev Koller and Dan Geraghty for making available HLA-B and HLA-C containing cosmids prior to publication.

PY - 1986/6

Y1 - 1986/6

N2 - Two DNA probes isolated from the region 5′ to the HLA-B gene are described. One of these, pCH6, detects a TaqI polymorphism which is correlated with serological alleles of HLA-B. Both probes are used to show a high level of DNA sequence homology between the 5′ flanking region of HLA-B and HLA-C.

AB - Two DNA probes isolated from the region 5′ to the HLA-B gene are described. One of these, pCH6, detects a TaqI polymorphism which is correlated with serological alleles of HLA-B. Both probes are used to show a high level of DNA sequence homology between the 5′ flanking region of HLA-B and HLA-C.

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ER -

Use of DNA probes from the 5′ flanking region of the HLA-B gene to examine polymorphism at the HLA-B locus

Abstract

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