Two DNA probes isolated from the region 5′ to the HLA-B gene are described. One of these, pCH6, detects a TaqI polymorphism which is correlated with serological alleles of HLA-B. Both probes are used to show a high level of DNA sequence homology between the 5′ flanking region of HLA-B and HLA-C.
Bibliographical noteFunding Information:
Supported by NIH Grants AI 18124 (HTO), AM 34502 (JDT) agrant from the Minnesota Medical Foundation and a grant from the Minnesota Chapter of the Arthritis Foundation. We thank Drs. Bev Koller and Dan Geraghty for making available HLA-B and HLA-C containing cosmids prior to publication.