Use of dantrolene plus multiple pulses to detect stress- susceptible porcine muscle

J. G. Quinlan, P. A. Iaizzo, G. A. Gronert, S. R. Taylor

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Twitch characteristics of tibialis anterior muscles in situ were examined in stress-susceptible and normal swine. Three groups of pigs were studied: (1) purebred Pietrain stress-susceptible, (2) purebred Yorkshire normal, and (3) a crossbred (Pietrain-Yorkshire) litter containing both stress-susceptible and normal animals. Purebred and crossbred stress-susceptible pigs provided qualitatively similar results, as did purebred and crossbred normal pigs. Single stimuli produced greater than normal peak tensions and faster rates of tension development in stress-susceptible animals. Multiple stimuli (2-6 pulses at 5-ms intervals) increased peak tensions and rates of tension development, but did not augment differences between normal and stress-susceptible pigs. Intravenous administration of dantrolene reduced peak tensions and rates of tension development in all groups for single and multiple stimuli. However, the reduction was significantly less (P < 0.01) for stress-susceptible pigs. Multiple stimuli (4-6 pulses) plus dantrolene amplified differences (P < 0.01) in contractile properties between normal and stress-susceptible skeletal muscles, with stress-susceptible muscles obtaining larger peak tensions and faster rates of tension development. Normal and stress-susceptible pigs may, therefore, be distinguished by these procedures.

Original languageEnglish (US)
Pages (from-to)1313-1320
Number of pages8
JournalJournal of applied physiology
Volume60
Issue number4
DOIs
StatePublished - 1986

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