Use of connectotyping on task functional MRI data reveals dynamic network level cross talking during task performance

Valeria Vazquez-Trejo, Binyam Nardos, Bradley L. Schlaggar, Damien A. Fair, Oscar Miranda-Dominguez

Research output: Contribution to journalArticlepeer-review

Abstract

Task-based functional MRI (fMRI) has greatly improved understanding of brain functioning, enabling the identification of brain areas associated with specific cognitive operations. Traditional analyses are limited to associating activation patterns in particular regions with specific cognitive operation, largely ignoring regional cross-talk or dynamic connectivity, which we propose is crucial for characterization of brain function in the context of task fMRI. We use connectotyping, which efficiently models functional brain connectivity to reveal the progression of temporal brain connectivity patterns in task fMRI. Connectotyping was employed on data from twenty-four participants (12 male, mean age 24.8 years, 2.57 std. dev) who performed a widely spaced event-related fMRI word vs. pseudoword decision task, where stimuli were presented every 20 s. After filtering for movement, we ended up with 15 participants that completed each trial and had enough usable data for our analyses. Connectivity matrices were calculated per participant across time for each stimuli type. A Repeated Measures ANOVA applied on the connectotypes was used to characterize differences across time for words and pseudowords. Our group level analyses found significantly different dynamic connectivity patterns during word vs. pseudoword processing between the Fronto-Parietal and Cingulo-Parietal Systems, areas involved in cognitive task control, memory retrieval, and semantic processing. Our findings support the presence of dynamic changes in functional connectivity during task execution and that such changes can be characterized using connectotyping but not with traditional Pearson’s correlations.

Original languageEnglish (US)
Article number951907
JournalFrontiers in Neuroscience
Volume16
DOIs
StatePublished - Oct 10 2022

Bibliographical note

Funding Information:
This project was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Grant: NIH R01 HD05707601 (BS), an OHSU Fellowship for Diversity and Inclusion in Research Program (OM-D), a Tartar Trust Award (OM-D), the OHSU Parkinson Center Pilot Grant Program (OM-D), and the Portland State University BUILD EXITO program, Grants: 5TL4GM118965-03, 5TL4GM118965-04, and 5TL4GM118965-05.

Publisher Copyright:
Copyright © 2022 Vazquez-Trejo, Nardos, Schlaggar, Fair and Miranda-Dominguez.

Keywords

  • BOLD
  • cognition
  • connectotyping
  • dynamic connectivity
  • fMRI
  • functional connectivity
  • task fMRI
  • widely spaced event-related fMRI

PubMed: MeSH publication types

  • Journal Article

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