Use of a whole blood substitute, fluosol-da 20%, after massive postpartum hemorrhage

Karen E. Karn, Paul L. Ogburn, Thomas Julian, Frank B. Cerra, Dale E Hammerschmidt, Gregory M Vercellotti

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Two patients with severe postpartum hemorrhage refused blood product transfusion for religious reasons. The patients' hemoglobin level had dropped to 3.0% or less after operative intervention, and the cardiac indexes on transfer to the tertiary care center were 8.0 and 7.3 L/minute per m2, respectively. Each received an infusion of Fluosol-DA 20% according to research protocol after obtaining informed written consent. Pulse rates and cardiac outputs dropped after the infusions. They were discharged from the hospital 17 and 15 days later with hemoglobins of 7.0 and 5.1%, respectively. Fluosol-DA 20% may be a useful adjunct for therapy of postpartum hemorrhage in women who refuse blood products for religious reasons.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalObstetrics and gynecology
Volume65
Issue number1
StatePublished - Jan 1985

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Blood Substitutes
Postpartum Hemorrhage
Hemoglobins
Informed Consent
Tertiary Care Centers
Blood Transfusion
Cardiac Output
Heart Rate
Research
glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination
fluosol
Therapeutics

Cite this

Karn, K. E., Ogburn, P. L., Julian, T., Cerra, F. B., Hammerschmidt, D. E., & Vercellotti, G. M. (1985). Use of a whole blood substitute, fluosol-da 20%, after massive postpartum hemorrhage. Obstetrics and gynecology, 65(1), 127-130.

Use of a whole blood substitute, fluosol-da 20%, after massive postpartum hemorrhage. / Karn, Karen E.; Ogburn, Paul L.; Julian, Thomas; Cerra, Frank B.; Hammerschmidt, Dale E; Vercellotti, Gregory M.

In: Obstetrics and gynecology, Vol. 65, No. 1, 01.1985, p. 127-130.

Research output: Contribution to journalArticle

Karn, KE, Ogburn, PL, Julian, T, Cerra, FB, Hammerschmidt, DE & Vercellotti, GM 1985, 'Use of a whole blood substitute, fluosol-da 20%, after massive postpartum hemorrhage', Obstetrics and gynecology, vol. 65, no. 1, pp. 127-130.
Karn KE, Ogburn PL, Julian T, Cerra FB, Hammerschmidt DE, Vercellotti GM. Use of a whole blood substitute, fluosol-da 20%, after massive postpartum hemorrhage. Obstetrics and gynecology. 1985 Jan;65(1):127-130.
Karn, Karen E. ; Ogburn, Paul L. ; Julian, Thomas ; Cerra, Frank B. ; Hammerschmidt, Dale E ; Vercellotti, Gregory M. / Use of a whole blood substitute, fluosol-da 20%, after massive postpartum hemorrhage. In: Obstetrics and gynecology. 1985 ; Vol. 65, No. 1. pp. 127-130.
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