Background: Chronic non-healing foot wounds are common complication in the diabetic population. Local radiant heat bandage has recently been proposed as an effective adjuvant. The purpose of this study was to evaluate the efficacy of such bandage in controlling infection in an ovine ischemic wound model. Material/Methods: Bilateral flank ischemic wounds were created in a total of 42 sheep. 14 sheep were challenged with Pseudomonas aeruginosa (PA), 13 with Escherichia Coil (EC), and 15 with Methicillin resistant staphylococcus aureus (MRSA). The left flank was designated the treatment. side and the right the control side. The radiant heat bandage was applied for a total of 10 clays. The animal were then euthanized and the wounds harvested for bacterial quantification. Results: 39 sheep completed the study. Mean bacterial counts were has follows: for MRSA, control 7.6x105 CFU/gm vs. heated 2.0x105 CFU/gm (p=0.16); for EC, control 1.1x106 CFU/gm vs. heated 2.7x105 CFU/gm (p=0.006); PA, control 1.7x106 CFU/gm vs. heated 3.9x109 CFU/gm (p=0.001). Conclusion: Non-contact radiant bandages controls bacterial growth in ischemic wounds infected with MRSA or EC and may potentially improve wound healing. Wounds infected with PA should no be submitted to such treatment.
|Original language||English (US)|
|Journal||Medical Science Monitor|
|State||Published - Aug 1 2002|
- Ischemic wound infection
- Non-contact radiant heat bandage