Use of a deslorelin implant for management of hyperandrogenism associated with excessive sex hormone production in a female spayed pet rabbit (Oryctolagus cuniculus)

Objectives: The GnRH analogue, deslorelin, is commonly used for hormonal suppression in a wide range of species. Case Description: A 5-year-old mixed breed spayed female pet rabbit (Oryctolagus cuniculus) presented for evaluation of behavioral changes including inappropriate urination and sexual aggression. Abdominal ultrasonography revealed left adrenal enlargement with a nodule located on the cranial pole. Increased concentrations of serum testosterone suggested adrenal pathology and hyperandrogenism. Subcutaneous placement of a 4.7 mg deslorelin implant intrascapularly resulted in lower testosterone levels, suppressed clinical signs, and decreased adrenal gland size. As of the submission of this paper (13 months later), presenting clinical signs have not returned and testosterone levels continue to remain in the normal reference range. Conclusion: This implant was successful at suppressing presenting clinical signs and lowering serm testosterone levels. Case Relevance: The clinical experience from this case suggests that this deslorelin implant may be used to manage clinical signs in similar cases where adrenalectomy may not be an option. The use of this implant in pet rabbits should be considered where it is ethically and legally allowed.