US Immigration Westernizes the Human Gut Microbiome

Pajau Vangay; Abigail J. Johnson; Tonya L. Ward; Gabriel A. Al-Ghalith; Robin R. Shields-Cutler; Benjamin M. Hillmann; Sarah K. Lucas; Lalit K. Beura; Emily A. Thompson; Lisa M. Till; Rodolfo Batres; Bwei Paw; Shannon L. Pergament; Pimpanitta Saenyakul; Mary Xiong; Austin D. Kim; Grant Kim; David Masopust; Eric C. Martens; Chaisiri Angkurawaranon; Rose McGready; Purna C. Kashyap; Kathleen A. Culhane-Pera; Dan Knights

doi:10.1016/j.cell.2018.10.029

US Immigration Westernizes the Human Gut Microbiome

Pajau Vangay, Abigail J. Johnson, Tonya L. Ward, Gabriel A. Al-Ghalith, Robin R. Shields-Cutler, Benjamin M. Hillmann, Sarah K. Lucas, Lalit K. Beura, Emily A. Thompson, Lisa M. Till, Rodolfo Batres, Bwei Paw, Shannon L. Pergament, Pimpanitta Saenyakul, Mary Xiong, Austin D. Kim, Grant Kim, David Masopust, Eric C. Martens, Chaisiri AngkurawaranonRose McGready, Purna C. Kashyap, Kathleen A. Culhane-Pera, Dan Knights

Research output: Contribution to journal › Article › peer-review

489 Scopus citations

Abstract

Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations. Migration from a non-western nation to the United States is found to be associated with a loss in gut microbiome diversity and function in a manner that may predispose individuals to metabolic disease.

Original language	English (US)
Pages (from-to)	962-972.e10
Journal	Cell
Volume	175
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2018.10.029
State	Published - Nov 1 2018

Bibliographical note

Funding Information:
We thank all of the participants in this study. We also thank the members of our community advisory boards, who provided critical feedback throughout the study: Bu Bu, Jamiey Cha, Yoha Christiansen, Pa Chua Vang, Duachi Her, Ku Ku Paw Lynn, Mayly Lochungvu, Mudah Takoni, Aye Mi San, Yeng Moua, Ko Nay Oo, Donna Vue Lee, Houa Vue-Her, Pakou Xiong, and Shoua Yang. Our work in Thailand would not have been possible without Ntxawm Lis, Yi Lis, Blooming Zion, Htoo Lay Paw, Moo Kho Paw, See Thoj, and Wirachon Yangyuenkun. We also thank Nurul Quratulaini Abd Salim Nast, Dominique Sabas, and Max Abramson for their assistance in the lab. We thank Ryan Hunter for his advice and assistance with planning. This work was supported by the University of Minnesota Clinical and Translational Science Institute ; the University of Minnesota Healthy Foods, Healthy Lives Institute ; the University of Minnesota Office of Diversity ; and the Graduate School at the University of Minnesota .

Funding Information:
We thank all of the participants in this study. We also thank the members of our community advisory boards, who provided critical feedback throughout the study: Bu Bu, Jamiey Cha, Yoha Christiansen, Pa Chua Vang, Duachi Her, Ku Ku Paw Lynn, Mayly Lochungvu, Mudah Takoni, Aye Mi San, Yeng Moua, Ko Nay Oo, Donna Vue Lee, Houa Vue-Her, Pakou Xiong, and Shoua Yang. Our work in Thailand would not have been possible without Ntxawm Lis, Yi Lis, Blooming Zion, Htoo Lay Paw, Moo Kho Paw, See Thoj, and Wirachon Yangyuenkun. We also thank Nurul Quratulaini Abd Salim Nast, Dominique Sabas, and Max Abramson for their assistance in the lab. We thank Ryan Hunter for his advice and assistance with planning. This work was supported by the University of Minnesota Clinical and Translational Science Institute; the University of Minnesota Healthy Foods, Healthy Lives Institute; the University of Minnesota Office of Diversity; and the Graduate School at the University of Minnesota.

Publisher Copyright:
© 2018 Elsevier Inc.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

Bacteriodes
Prevotella
immigrant health
immigration
metagenomics
microbiome
microbiota
obesity
refugee health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.cell.2018.10.029

Find It

Find It at U of M Libraries

Cite this

Vangay, P., Johnson, A. J., Ward, T. L., Al-Ghalith, G. A., Shields-Cutler, R. R., Hillmann, B. M., Lucas, S. K., Beura, L. K., Thompson, E. A., Till, L. M., Batres, R., Paw, B., Pergament, S. L., Saenyakul, P., Xiong, M., Kim, A. D., Kim, G., Masopust, D., Martens, E. C., ... Knights, D. (2018). US Immigration Westernizes the Human Gut Microbiome. Cell, 175(4), 962-972.e10. https://doi.org/10.1016/j.cell.2018.10.029

Vangay, P, Johnson, AJ, Ward, TL, Al-Ghalith, GA, Shields-Cutler, RR, Hillmann, BM, Lucas, SK, Beura, LK, Thompson, EA, Till, LM, Batres, R, Paw, B, Pergament, SL, Saenyakul, P, Xiong, M, Kim, AD, Kim, G, Masopust, D, Martens, EC, Angkurawaranon, C, McGready, R, Kashyap, PC, Culhane-Pera, KA & Knights, D 2018, 'US Immigration Westernizes the Human Gut Microbiome', Cell, vol. 175, no. 4, pp. 962-972.e10. https://doi.org/10.1016/j.cell.2018.10.029

@article{a41078dda8534fbfa796a09f34acd1e5,

title = "US Immigration Westernizes the Human Gut Microbiome",

abstract = "Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations. Migration from a non-western nation to the United States is found to be associated with a loss in gut microbiome diversity and function in a manner that may predispose individuals to metabolic disease.",

keywords = "Bacteriodes, Prevotella, immigrant health, immigration, metagenomics, microbiome, microbiota, obesity, refugee health",

author = "Pajau Vangay and Johnson, {Abigail J.} and Ward, {Tonya L.} and Al-Ghalith, {Gabriel A.} and Shields-Cutler, {Robin R.} and Hillmann, {Benjamin M.} and Lucas, {Sarah K.} and Beura, {Lalit K.} and Thompson, {Emily A.} and Till, {Lisa M.} and Rodolfo Batres and Bwei Paw and Pergament, {Shannon L.} and Pimpanitta Saenyakul and Mary Xiong and Kim, {Austin D.} and Grant Kim and David Masopust and Martens, {Eric C.} and Chaisiri Angkurawaranon and Rose McGready and Kashyap, {Purna C.} and Culhane-Pera, {Kathleen A.} and Dan Knights",

note = "Funding Information: We thank all of the participants in this study. We also thank the members of our community advisory boards, who provided critical feedback throughout the study: Bu Bu, Jamiey Cha, Yoha Christiansen, Pa Chua Vang, Duachi Her, Ku Ku Paw Lynn, Mayly Lochungvu, Mudah Takoni, Aye Mi San, Yeng Moua, Ko Nay Oo, Donna Vue Lee, Houa Vue-Her, Pakou Xiong, and Shoua Yang. Our work in Thailand would not have been possible without Ntxawm Lis, Yi Lis, Blooming Zion, Htoo Lay Paw, Moo Kho Paw, See Thoj, and Wirachon Yangyuenkun. We also thank Nurul Quratulaini Abd Salim Nast, Dominique Sabas, and Max Abramson for their assistance in the lab. We thank Ryan Hunter for his advice and assistance with planning. This work was supported by the University of Minnesota Clinical and Translational Science Institute ; the University of Minnesota Healthy Foods, Healthy Lives Institute ; the University of Minnesota Office of Diversity ; and the Graduate School at the University of Minnesota . Funding Information: We thank all of the participants in this study. We also thank the members of our community advisory boards, who provided critical feedback throughout the study: Bu Bu, Jamiey Cha, Yoha Christiansen, Pa Chua Vang, Duachi Her, Ku Ku Paw Lynn, Mayly Lochungvu, Mudah Takoni, Aye Mi San, Yeng Moua, Ko Nay Oo, Donna Vue Lee, Houa Vue-Her, Pakou Xiong, and Shoua Yang. Our work in Thailand would not have been possible without Ntxawm Lis, Yi Lis, Blooming Zion, Htoo Lay Paw, Moo Kho Paw, See Thoj, and Wirachon Yangyuenkun. We also thank Nurul Quratulaini Abd Salim Nast, Dominique Sabas, and Max Abramson for their assistance in the lab. We thank Ryan Hunter for his advice and assistance with planning. This work was supported by the University of Minnesota Clinical and Translational Science Institute; the University of Minnesota Healthy Foods, Healthy Lives Institute; the University of Minnesota Office of Diversity; and the Graduate School at the University of Minnesota. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2018",

month = nov,

day = "1",

doi = "10.1016/j.cell.2018.10.029",

language = "English (US)",

volume = "175",

pages = "962--972.e10",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - US Immigration Westernizes the Human Gut Microbiome

AU - Vangay, Pajau

AU - Johnson, Abigail J.

AU - Ward, Tonya L.

AU - Al-Ghalith, Gabriel A.

AU - Shields-Cutler, Robin R.

AU - Hillmann, Benjamin M.

AU - Lucas, Sarah K.

AU - Beura, Lalit K.

AU - Thompson, Emily A.

AU - Till, Lisa M.

AU - Batres, Rodolfo

AU - Paw, Bwei

AU - Pergament, Shannon L.

AU - Saenyakul, Pimpanitta

AU - Xiong, Mary

AU - Kim, Austin D.

AU - Kim, Grant

AU - Masopust, David

AU - Martens, Eric C.

AU - Angkurawaranon, Chaisiri

AU - McGready, Rose

AU - Kashyap, Purna C.

AU - Culhane-Pera, Kathleen A.

AU - Knights, Dan

N1 - Funding Information: We thank all of the participants in this study. We also thank the members of our community advisory boards, who provided critical feedback throughout the study: Bu Bu, Jamiey Cha, Yoha Christiansen, Pa Chua Vang, Duachi Her, Ku Ku Paw Lynn, Mayly Lochungvu, Mudah Takoni, Aye Mi San, Yeng Moua, Ko Nay Oo, Donna Vue Lee, Houa Vue-Her, Pakou Xiong, and Shoua Yang. Our work in Thailand would not have been possible without Ntxawm Lis, Yi Lis, Blooming Zion, Htoo Lay Paw, Moo Kho Paw, See Thoj, and Wirachon Yangyuenkun. We also thank Nurul Quratulaini Abd Salim Nast, Dominique Sabas, and Max Abramson for their assistance in the lab. We thank Ryan Hunter for his advice and assistance with planning. This work was supported by the University of Minnesota Clinical and Translational Science Institute ; the University of Minnesota Healthy Foods, Healthy Lives Institute ; the University of Minnesota Office of Diversity ; and the Graduate School at the University of Minnesota . Funding Information: We thank all of the participants in this study. We also thank the members of our community advisory boards, who provided critical feedback throughout the study: Bu Bu, Jamiey Cha, Yoha Christiansen, Pa Chua Vang, Duachi Her, Ku Ku Paw Lynn, Mayly Lochungvu, Mudah Takoni, Aye Mi San, Yeng Moua, Ko Nay Oo, Donna Vue Lee, Houa Vue-Her, Pakou Xiong, and Shoua Yang. Our work in Thailand would not have been possible without Ntxawm Lis, Yi Lis, Blooming Zion, Htoo Lay Paw, Moo Kho Paw, See Thoj, and Wirachon Yangyuenkun. We also thank Nurul Quratulaini Abd Salim Nast, Dominique Sabas, and Max Abramson for their assistance in the lab. We thank Ryan Hunter for his advice and assistance with planning. This work was supported by the University of Minnesota Clinical and Translational Science Institute; the University of Minnesota Healthy Foods, Healthy Lives Institute; the University of Minnesota Office of Diversity; and the Graduate School at the University of Minnesota. Publisher Copyright: © 2018 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations. Migration from a non-western nation to the United States is found to be associated with a loss in gut microbiome diversity and function in a manner that may predispose individuals to metabolic disease.

AB - Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations. Migration from a non-western nation to the United States is found to be associated with a loss in gut microbiome diversity and function in a manner that may predispose individuals to metabolic disease.

KW - Bacteriodes

KW - Prevotella

KW - immigrant health

KW - immigration

KW - metagenomics

KW - microbiome

KW - microbiota

KW - obesity

KW - refugee health

UR - http://www.scopus.com/inward/record.url?scp=85055249203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055249203&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2018.10.029

DO - 10.1016/j.cell.2018.10.029

M3 - Article

C2 - 30388453

AN - SCOPUS:85055249203

SN - 0092-8674

VL - 175

SP - 962-972.e10

JO - Cell

JF - Cell

IS - 4

ER -

US Immigration Westernizes the Human Gut Microbiome

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this