Urinary urea: Are currently available methods adequate for revival of an almost abandoned test?

J. Eckfeldt, A. S. Levine, C. Greiner, M. Kershaw

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Measurement of urinary urea excretion has been suggested as a means of estimating nitrogen balance in hospitalized patients who are malnourished. Because proficiency-testing surveys show gross variations in mean urea as determined by various automated methods and extremely poor precision occasionally, we compared urinary urea measurements and ammonia interference in three widely used methods. The coupled urease/glutamate dehydrogenase method (used in the DuPont aca) showed positive interference from ammonia, as expected; with the diacetylmonoxime (Technicon 12/60) and the urease conductivity (Beckman ASTRA) methods we saw no such interference. Generally, interference by ammonia is < 10%, but (rarely) it may exceed 25%. However, if urine specimens are properly diluted and potential sources of interference recognized, all three methods appear capable of providing clinically useful data.

Original languageEnglish (US)
Pages (from-to)1500-1502
Number of pages3
JournalClinical chemistry
Volume28
Issue number7
StatePublished - Jan 1 1982

Fingerprint

Dive into the research topics of 'Urinary urea: Are currently available methods adequate for revival of an almost abandoned test?'. Together they form a unique fingerprint.

Cite this