Urinary phthalate metabolite concentrations in relation to history of infertility and use of assisted reproductive technology

Snigdha Alur, Hongyue Wang, Kathy Hoeger, Shanna H. Swan, Sheela Sathyanarayana, Bruce B Redmon, Ruby H Nguyen, Emily S. Barrett

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective To examine urinary phthalate metabolite concentrations in pregnant women with planned pregnancies in relation to history of infertility and use of assisted reproductive technology (ART). Design Phthalate metabolite concentrations were measured in first-trimester urine samples collected from women participating in a prospective pregnancy cohort study. Setting Prenatal clinics. Patient(s) A total of 750 women, of whom 86 had a history of infertility. Forty-one women used ART to conceive. Intervention(s) None. Main Outcome Measure(s) Primary outcomes were concentrations of four metabolites of diethylhexyl phthalate (DEHP) and their molar sum (∑DEHP). Multivariable analyses compared phthalate metabolite levels in [1] women reporting a history of infertility vs. those who did not (comparison group); and [2] those who used ART to conceive the index pregnancy vs. women with a history of infertility who did not use ART. Result(s) Among women with a history of infertility, ∑DEHP was significantly lower in women who conceived after ART compared with those who did not (geometric mean ratio: 0.83; 95% confidence interval 0.71-0.98). Similar significant associations were observed for all of the individual DEHP metabolites. There were no differences in DEHP metabolite concentrations between women with a history of infertility and the comparison group. Conclusion(s) Women who used ART to conceive had lower first-trimester phthalate metabolite concentrations than women with a history of infertility who did not use ART. Further research is needed to explore whether those pursuing fertility treatments take precautions to avoid exposure to environmental toxins, to improve treatment outcomes.

Original languageEnglish (US)
Pages (from-to)1227-1235
Number of pages9
JournalFertility and Sterility
Volume104
Issue number5
DOIs
StatePublished - Nov 1 2015

Fingerprint

Assisted Reproductive Techniques
Infertility
Diethylhexyl Phthalate
First Pregnancy Trimester
phthalic acid
Pregnancy
Environmental Exposure
Family Planning Services
Fertility
Pregnant Women
Cohort Studies
Outcome Assessment (Health Care)
Urine
Confidence Intervals

Keywords

  • ART
  • Phthalate
  • endocrine-disrupting chemicals (EDCs)
  • infertility

Cite this

Urinary phthalate metabolite concentrations in relation to history of infertility and use of assisted reproductive technology. / Alur, Snigdha; Wang, Hongyue; Hoeger, Kathy; Swan, Shanna H.; Sathyanarayana, Sheela; Redmon, Bruce B; Nguyen, Ruby H; Barrett, Emily S.

In: Fertility and Sterility, Vol. 104, No. 5, 01.11.2015, p. 1227-1235.

Research output: Contribution to journalArticle

Alur, Snigdha ; Wang, Hongyue ; Hoeger, Kathy ; Swan, Shanna H. ; Sathyanarayana, Sheela ; Redmon, Bruce B ; Nguyen, Ruby H ; Barrett, Emily S. / Urinary phthalate metabolite concentrations in relation to history of infertility and use of assisted reproductive technology. In: Fertility and Sterility. 2015 ; Vol. 104, No. 5. pp. 1227-1235.
@article{9ab8217b91824bf19bb250e2f3f9f303,
title = "Urinary phthalate metabolite concentrations in relation to history of infertility and use of assisted reproductive technology",
abstract = "Objective To examine urinary phthalate metabolite concentrations in pregnant women with planned pregnancies in relation to history of infertility and use of assisted reproductive technology (ART). Design Phthalate metabolite concentrations were measured in first-trimester urine samples collected from women participating in a prospective pregnancy cohort study. Setting Prenatal clinics. Patient(s) A total of 750 women, of whom 86 had a history of infertility. Forty-one women used ART to conceive. Intervention(s) None. Main Outcome Measure(s) Primary outcomes were concentrations of four metabolites of diethylhexyl phthalate (DEHP) and their molar sum (∑DEHP). Multivariable analyses compared phthalate metabolite levels in [1] women reporting a history of infertility vs. those who did not (comparison group); and [2] those who used ART to conceive the index pregnancy vs. women with a history of infertility who did not use ART. Result(s) Among women with a history of infertility, ∑DEHP was significantly lower in women who conceived after ART compared with those who did not (geometric mean ratio: 0.83; 95{\%} confidence interval 0.71-0.98). Similar significant associations were observed for all of the individual DEHP metabolites. There were no differences in DEHP metabolite concentrations between women with a history of infertility and the comparison group. Conclusion(s) Women who used ART to conceive had lower first-trimester phthalate metabolite concentrations than women with a history of infertility who did not use ART. Further research is needed to explore whether those pursuing fertility treatments take precautions to avoid exposure to environmental toxins, to improve treatment outcomes.",
keywords = "ART, Phthalate, endocrine-disrupting chemicals (EDCs), infertility",
author = "Snigdha Alur and Hongyue Wang and Kathy Hoeger and Swan, {Shanna H.} and Sheela Sathyanarayana and Redmon, {Bruce B} and Nguyen, {Ruby H} and Barrett, {Emily S.}",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.fertnstert.2015.07.1150",
language = "English (US)",
volume = "104",
pages = "1227--1235",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Urinary phthalate metabolite concentrations in relation to history of infertility and use of assisted reproductive technology

AU - Alur, Snigdha

AU - Wang, Hongyue

AU - Hoeger, Kathy

AU - Swan, Shanna H.

AU - Sathyanarayana, Sheela

AU - Redmon, Bruce B

AU - Nguyen, Ruby H

AU - Barrett, Emily S.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Objective To examine urinary phthalate metabolite concentrations in pregnant women with planned pregnancies in relation to history of infertility and use of assisted reproductive technology (ART). Design Phthalate metabolite concentrations were measured in first-trimester urine samples collected from women participating in a prospective pregnancy cohort study. Setting Prenatal clinics. Patient(s) A total of 750 women, of whom 86 had a history of infertility. Forty-one women used ART to conceive. Intervention(s) None. Main Outcome Measure(s) Primary outcomes were concentrations of four metabolites of diethylhexyl phthalate (DEHP) and their molar sum (∑DEHP). Multivariable analyses compared phthalate metabolite levels in [1] women reporting a history of infertility vs. those who did not (comparison group); and [2] those who used ART to conceive the index pregnancy vs. women with a history of infertility who did not use ART. Result(s) Among women with a history of infertility, ∑DEHP was significantly lower in women who conceived after ART compared with those who did not (geometric mean ratio: 0.83; 95% confidence interval 0.71-0.98). Similar significant associations were observed for all of the individual DEHP metabolites. There were no differences in DEHP metabolite concentrations between women with a history of infertility and the comparison group. Conclusion(s) Women who used ART to conceive had lower first-trimester phthalate metabolite concentrations than women with a history of infertility who did not use ART. Further research is needed to explore whether those pursuing fertility treatments take precautions to avoid exposure to environmental toxins, to improve treatment outcomes.

AB - Objective To examine urinary phthalate metabolite concentrations in pregnant women with planned pregnancies in relation to history of infertility and use of assisted reproductive technology (ART). Design Phthalate metabolite concentrations were measured in first-trimester urine samples collected from women participating in a prospective pregnancy cohort study. Setting Prenatal clinics. Patient(s) A total of 750 women, of whom 86 had a history of infertility. Forty-one women used ART to conceive. Intervention(s) None. Main Outcome Measure(s) Primary outcomes were concentrations of four metabolites of diethylhexyl phthalate (DEHP) and their molar sum (∑DEHP). Multivariable analyses compared phthalate metabolite levels in [1] women reporting a history of infertility vs. those who did not (comparison group); and [2] those who used ART to conceive the index pregnancy vs. women with a history of infertility who did not use ART. Result(s) Among women with a history of infertility, ∑DEHP was significantly lower in women who conceived after ART compared with those who did not (geometric mean ratio: 0.83; 95% confidence interval 0.71-0.98). Similar significant associations were observed for all of the individual DEHP metabolites. There were no differences in DEHP metabolite concentrations between women with a history of infertility and the comparison group. Conclusion(s) Women who used ART to conceive had lower first-trimester phthalate metabolite concentrations than women with a history of infertility who did not use ART. Further research is needed to explore whether those pursuing fertility treatments take precautions to avoid exposure to environmental toxins, to improve treatment outcomes.

KW - ART

KW - Phthalate

KW - endocrine-disrupting chemicals (EDCs)

KW - infertility

UR - http://www.scopus.com/inward/record.url?scp=84946483095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946483095&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2015.07.1150

DO - 10.1016/j.fertnstert.2015.07.1150

M3 - Article

VL - 104

SP - 1227

EP - 1235

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 5

ER -