Urinary oxidative stress biomarkers are associated with preterm birth: an Environmental Influences on Child Health Outcomes program study

of program collaborators for Environmental Influences on Child Health Outcomes

doi:10.1016/j.ajog.2022.11.1282

Urinary oxidative stress biomarkers are associated with preterm birth: an Environmental Influences on Child Health Outcomes program study

of program collaborators for Environmental Influences on Child Health Outcomes

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: Preterm birth is the leading cause of infant morbidity and mortality worldwide. Elevated levels of oxidative stress have been associated with an increased risk of delivering before term. However, most studies testing this hypothesis have been conducted in racially and demographically homogenous study populations, which do not reflect the diversity within the United States. Objective: We leveraged 4 cohorts participating in the Environmental Influences on Child Health Outcomes Program to conduct the largest study to date examining biomarkers of oxidative stress and preterm birth (N=1916). Furthermore, we hypothesized that elevated oxidative stress would be associated with higher odds of preterm birth, particularly preterm birth of spontaneous origin. Study Design: This study was a pooled analysis and meta-analysis of 4 birth cohorts spanning multiple geographic regions in the mainland United States and Puerto Rico (208 preterm births and 1708 full-term births). Of note, 8-iso-prostaglandin-F_2α, 2,3-dinor-5,6-dihydro-8-iso-prostaglandin-F_2α (F₂-IsoP-M; the major 8-iso-prostaglandin-F_2α metabolite), and prostaglandin-F_2α were measured in urine samples obtained during the second and third trimesters of pregnancy. Logistic regression was used to calculate adjusted odds ratios and 95% confidence intervals for the associations between averaged biomarker concentrations for each participant and all preterm births, spontaneous preterm births, nonspontaneous preterm births (births of medically indicated or unknown origin), and categories of preterm birth (early, moderate, and late). Individual oxidative stress biomarkers were examined in separate models. Results: Approximately 11% of our analytical sample was born before term. Relative to full-term births, an interquartile range increase in averaged concentrations of F₂-IsoP-M was associated with higher odds of all preterm births (odds ratio, 1.29; 95% confidence interval, 1.11–1.51), with a stronger association observed for spontaneous preterm birth (odds ratio, 1.47; 95% confidence interval, 1.16–1.90). An interquartile range increase in averaged concentrations of 8-iso-prostaglandin-F_2α was similarly associated with higher odds of all preterm births (odds ratio, 1.19; 95% confidence interval, 0.94–1.50). The results from our meta-analysis were similar to those from the pooled combined cohort analysis. Conclusion: Here, oxidative stress, as measured by 8-iso-prostaglandin-F_2α, F₂-IsoP-M, and prostaglandin-F_2α in urine, was associated with increased odds of preterm birth, particularly preterm birth of spontaneous origin and delivery before 34 completed weeks of gestation.

Original language	English (US)
Pages (from-to)	576.e1-576.e22
Journal	American journal of obstetrics and gynecology
Volume	228
Issue number	5
DOIs	https://doi.org/10.1016/j.ajog.2022.11.1282
State	Published - May 2023

Bibliographical note

Funding Information:
Research reported in this publication was supported by the Environmental Influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health (NIH), under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (Pro-Core), 5U2COD023375-05 (Opportunities and Infrastructure Fund), UG3OD023251, UH3OD023251, UG3OD023272, UH3OD023272, UG3OD023271, UH3OD023271, UG3023305, and UH3OD023305. This work was additionally supported by the Children's Environmental Health and Disease Prevention Research Center (grant numbers ES022848 and RD83543401), T32 NIH Institution Training Grant Predoctoral Traineeships in Endocrine, Developmental, and Reproductive Toxicology (grant number ES007326), US Environmental Protection Agency (grant number RD83543301), National Institute of Environmental Health Sciences (NIEHS; grant numbers P42ES017198, P50ES026049, P01ES022841, R01ES02705, R01ES025169, R01ES016863, P30ES019776, P30ES030284, and P30ES005022), and the Intramural Research Program, NIEHS (grant number ZIAES103313). G.L.M. is supported by the Vanderbilt Diabetes Research Center with funding from the National Institute of Diabetes and Digestive and Kidney Diseases (grant number DK-20593). L.G.K. is supported by an NIH grant R00ES030403.

Publisher Copyright:
© 2022 Elsevier Inc.

Keywords

8-iso-prostaglandin-F
F-IsoP-M
adverse pregnancy outcomes
isoprostanes
lipid peroxidation
oxidative stress
oxylipins
preterm birth
preterm labor
preterm premature rupture of membranes
prostaglandin F
spontaneous preterm birth

PubMed: MeSH publication types

Meta-Analysis
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ajog.2022.11.1282

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Urinary oxidative stress biomarkers are associated with preterm birth: an Environmental Influences on Child Health Outcomes program study. / of program collaborators for Environmental Influences on Child Health Outcomes.
In: American journal of obstetrics and gynecology, Vol. 228, No. 5, 05.2023, p. 576.e1-576.e22.

Research output: Contribution to journal › Article › peer-review

@article{5ac696ebfb284b5aaf55e920b6091c81,

title = "Urinary oxidative stress biomarkers are associated with preterm birth: an Environmental Influences on Child Health Outcomes program study",

abstract = "Background: Preterm birth is the leading cause of infant morbidity and mortality worldwide. Elevated levels of oxidative stress have been associated with an increased risk of delivering before term. However, most studies testing this hypothesis have been conducted in racially and demographically homogenous study populations, which do not reflect the diversity within the United States. Objective: We leveraged 4 cohorts participating in the Environmental Influences on Child Health Outcomes Program to conduct the largest study to date examining biomarkers of oxidative stress and preterm birth (N=1916). Furthermore, we hypothesized that elevated oxidative stress would be associated with higher odds of preterm birth, particularly preterm birth of spontaneous origin. Study Design: This study was a pooled analysis and meta-analysis of 4 birth cohorts spanning multiple geographic regions in the mainland United States and Puerto Rico (208 preterm births and 1708 full-term births). Of note, 8-iso-prostaglandin-F2α, 2,3-dinor-5,6-dihydro-8-iso-prostaglandin-F2α (F2-IsoP-M; the major 8-iso-prostaglandin-F2α metabolite), and prostaglandin-F2α were measured in urine samples obtained during the second and third trimesters of pregnancy. Logistic regression was used to calculate adjusted odds ratios and 95% confidence intervals for the associations between averaged biomarker concentrations for each participant and all preterm births, spontaneous preterm births, nonspontaneous preterm births (births of medically indicated or unknown origin), and categories of preterm birth (early, moderate, and late). Individual oxidative stress biomarkers were examined in separate models. Results: Approximately 11% of our analytical sample was born before term. Relative to full-term births, an interquartile range increase in averaged concentrations of F2-IsoP-M was associated with higher odds of all preterm births (odds ratio, 1.29; 95% confidence interval, 1.11–1.51), with a stronger association observed for spontaneous preterm birth (odds ratio, 1.47; 95% confidence interval, 1.16–1.90). An interquartile range increase in averaged concentrations of 8-iso-prostaglandin-F2α was similarly associated with higher odds of all preterm births (odds ratio, 1.19; 95% confidence interval, 0.94–1.50). The results from our meta-analysis were similar to those from the pooled combined cohort analysis. Conclusion: Here, oxidative stress, as measured by 8-iso-prostaglandin-F2α, F2-IsoP-M, and prostaglandin-F2α in urine, was associated with increased odds of preterm birth, particularly preterm birth of spontaneous origin and delivery before 34 completed weeks of gestation.",

keywords = "8-iso-prostaglandin-F, F-IsoP-M, adverse pregnancy outcomes, isoprostanes, lipid peroxidation, oxidative stress, oxylipins, preterm birth, preterm labor, preterm premature rupture of membranes, prostaglandin F, spontaneous preterm birth",

author = "{of program collaborators for Environmental Influences on Child Health Outcomes} and Eick, {Stephanie M.} and Geiger, {Sarah D.} and Akram Alshawabkeh and Max Aung and Barrett, {Emily S.} and Nicole Bush and Carroll, {Kecia N.} and Cordero, {Jos{\'e} F.} and Goin, {Dana E.} and Ferguson, {Kelly K.} and Kahn, {Linda G.} and Donghai Liang and Meeker, {John D.} and Milne, {Ginger L.} and Nguyen, {Ruby H.N.} and Padula, {Amy M.} and Sheela Sathyanarayana and Taibl, {Kaitlin R.} and Schantz, {Susan L.} and Woodruff, {Tracey J.} and Rachel Morello-Frosch",

note = "Funding Information: Research reported in this publication was supported by the Environmental Influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health (NIH), under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (Pro-Core), 5U2COD023375-05 (Opportunities and Infrastructure Fund), UG3OD023251, UH3OD023251, UG3OD023272, UH3OD023272, UG3OD023271, UH3OD023271, UG3023305, and UH3OD023305. This work was additionally supported by the Children's Environmental Health and Disease Prevention Research Center (grant numbers ES022848 and RD83543401), T32 NIH Institution Training Grant Predoctoral Traineeships in Endocrine, Developmental, and Reproductive Toxicology (grant number ES007326), US Environmental Protection Agency (grant number RD83543301), National Institute of Environmental Health Sciences (NIEHS; grant numbers P42ES017198, P50ES026049, P01ES022841, R01ES02705, R01ES025169, R01ES016863, P30ES019776, P30ES030284, and P30ES005022), and the Intramural Research Program, NIEHS (grant number ZIAES103313). G.L.M. is supported by the Vanderbilt Diabetes Research Center with funding from the National Institute of Diabetes and Digestive and Kidney Diseases (grant number DK-20593). L.G.K. is supported by an NIH grant R00ES030403. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2023",

month = may,

doi = "10.1016/j.ajog.2022.11.1282",

language = "English (US)",

volume = "228",

pages = "576.e1--576.e22",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

publisher = "Elsevier Inc.",

number = "5",

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TY - JOUR

T1 - Urinary oxidative stress biomarkers are associated with preterm birth

T2 - an Environmental Influences on Child Health Outcomes program study

AU - of program collaborators for Environmental Influences on Child Health Outcomes

AU - Eick, Stephanie M.

AU - Geiger, Sarah D.

AU - Alshawabkeh, Akram

AU - Aung, Max

AU - Barrett, Emily S.

AU - Bush, Nicole

AU - Carroll, Kecia N.

AU - Cordero, José F.

AU - Goin, Dana E.

AU - Ferguson, Kelly K.

AU - Kahn, Linda G.

AU - Liang, Donghai

AU - Meeker, John D.

AU - Milne, Ginger L.

AU - Nguyen, Ruby H.N.

AU - Padula, Amy M.

AU - Sathyanarayana, Sheela

AU - Taibl, Kaitlin R.

AU - Schantz, Susan L.

AU - Woodruff, Tracey J.

AU - Morello-Frosch, Rachel

N1 - Funding Information: Research reported in this publication was supported by the Environmental Influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health (NIH), under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (Pro-Core), 5U2COD023375-05 (Opportunities and Infrastructure Fund), UG3OD023251, UH3OD023251, UG3OD023272, UH3OD023272, UG3OD023271, UH3OD023271, UG3023305, and UH3OD023305. This work was additionally supported by the Children's Environmental Health and Disease Prevention Research Center (grant numbers ES022848 and RD83543401), T32 NIH Institution Training Grant Predoctoral Traineeships in Endocrine, Developmental, and Reproductive Toxicology (grant number ES007326), US Environmental Protection Agency (grant number RD83543301), National Institute of Environmental Health Sciences (NIEHS; grant numbers P42ES017198, P50ES026049, P01ES022841, R01ES02705, R01ES025169, R01ES016863, P30ES019776, P30ES030284, and P30ES005022), and the Intramural Research Program, NIEHS (grant number ZIAES103313). G.L.M. is supported by the Vanderbilt Diabetes Research Center with funding from the National Institute of Diabetes and Digestive and Kidney Diseases (grant number DK-20593). L.G.K. is supported by an NIH grant R00ES030403. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2023/5

Y1 - 2023/5

N2 - Background: Preterm birth is the leading cause of infant morbidity and mortality worldwide. Elevated levels of oxidative stress have been associated with an increased risk of delivering before term. However, most studies testing this hypothesis have been conducted in racially and demographically homogenous study populations, which do not reflect the diversity within the United States. Objective: We leveraged 4 cohorts participating in the Environmental Influences on Child Health Outcomes Program to conduct the largest study to date examining biomarkers of oxidative stress and preterm birth (N=1916). Furthermore, we hypothesized that elevated oxidative stress would be associated with higher odds of preterm birth, particularly preterm birth of spontaneous origin. Study Design: This study was a pooled analysis and meta-analysis of 4 birth cohorts spanning multiple geographic regions in the mainland United States and Puerto Rico (208 preterm births and 1708 full-term births). Of note, 8-iso-prostaglandin-F2α, 2,3-dinor-5,6-dihydro-8-iso-prostaglandin-F2α (F2-IsoP-M; the major 8-iso-prostaglandin-F2α metabolite), and prostaglandin-F2α were measured in urine samples obtained during the second and third trimesters of pregnancy. Logistic regression was used to calculate adjusted odds ratios and 95% confidence intervals for the associations between averaged biomarker concentrations for each participant and all preterm births, spontaneous preterm births, nonspontaneous preterm births (births of medically indicated or unknown origin), and categories of preterm birth (early, moderate, and late). Individual oxidative stress biomarkers were examined in separate models. Results: Approximately 11% of our analytical sample was born before term. Relative to full-term births, an interquartile range increase in averaged concentrations of F2-IsoP-M was associated with higher odds of all preterm births (odds ratio, 1.29; 95% confidence interval, 1.11–1.51), with a stronger association observed for spontaneous preterm birth (odds ratio, 1.47; 95% confidence interval, 1.16–1.90). An interquartile range increase in averaged concentrations of 8-iso-prostaglandin-F2α was similarly associated with higher odds of all preterm births (odds ratio, 1.19; 95% confidence interval, 0.94–1.50). The results from our meta-analysis were similar to those from the pooled combined cohort analysis. Conclusion: Here, oxidative stress, as measured by 8-iso-prostaglandin-F2α, F2-IsoP-M, and prostaglandin-F2α in urine, was associated with increased odds of preterm birth, particularly preterm birth of spontaneous origin and delivery before 34 completed weeks of gestation.

AB - Background: Preterm birth is the leading cause of infant morbidity and mortality worldwide. Elevated levels of oxidative stress have been associated with an increased risk of delivering before term. However, most studies testing this hypothesis have been conducted in racially and demographically homogenous study populations, which do not reflect the diversity within the United States. Objective: We leveraged 4 cohorts participating in the Environmental Influences on Child Health Outcomes Program to conduct the largest study to date examining biomarkers of oxidative stress and preterm birth (N=1916). Furthermore, we hypothesized that elevated oxidative stress would be associated with higher odds of preterm birth, particularly preterm birth of spontaneous origin. Study Design: This study was a pooled analysis and meta-analysis of 4 birth cohorts spanning multiple geographic regions in the mainland United States and Puerto Rico (208 preterm births and 1708 full-term births). Of note, 8-iso-prostaglandin-F2α, 2,3-dinor-5,6-dihydro-8-iso-prostaglandin-F2α (F2-IsoP-M; the major 8-iso-prostaglandin-F2α metabolite), and prostaglandin-F2α were measured in urine samples obtained during the second and third trimesters of pregnancy. Logistic regression was used to calculate adjusted odds ratios and 95% confidence intervals for the associations between averaged biomarker concentrations for each participant and all preterm births, spontaneous preterm births, nonspontaneous preterm births (births of medically indicated or unknown origin), and categories of preterm birth (early, moderate, and late). Individual oxidative stress biomarkers were examined in separate models. Results: Approximately 11% of our analytical sample was born before term. Relative to full-term births, an interquartile range increase in averaged concentrations of F2-IsoP-M was associated with higher odds of all preterm births (odds ratio, 1.29; 95% confidence interval, 1.11–1.51), with a stronger association observed for spontaneous preterm birth (odds ratio, 1.47; 95% confidence interval, 1.16–1.90). An interquartile range increase in averaged concentrations of 8-iso-prostaglandin-F2α was similarly associated with higher odds of all preterm births (odds ratio, 1.19; 95% confidence interval, 0.94–1.50). The results from our meta-analysis were similar to those from the pooled combined cohort analysis. Conclusion: Here, oxidative stress, as measured by 8-iso-prostaglandin-F2α, F2-IsoP-M, and prostaglandin-F2α in urine, was associated with increased odds of preterm birth, particularly preterm birth of spontaneous origin and delivery before 34 completed weeks of gestation.

KW - 8-iso-prostaglandin-F

KW - F-IsoP-M

KW - adverse pregnancy outcomes

KW - isoprostanes

KW - lipid peroxidation

KW - oxidative stress

KW - oxylipins

KW - preterm birth

KW - preterm labor

KW - preterm premature rupture of membranes

KW - prostaglandin F

KW - spontaneous preterm birth

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U2 - 10.1016/j.ajog.2022.11.1282

DO - 10.1016/j.ajog.2022.11.1282

M3 - Article

C2 - 36400174

AN - SCOPUS:85143288035

SN - 0002-9378

VL - 228

SP - 576.e1-576.e22

JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

IS - 5

ER -

Urinary oxidative stress biomarkers are associated with preterm birth: an Environmental Influences on Child Health Outcomes program study

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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