Urinary oxidative stress biomarkers and accelerated time to spontaneous delivery

Emma M. Rosen, Thomas J. van ‘t Erve, Jonathan Boss, Sheela Sathyanarayana, Emily S. Barrett, Ruby H.N. Nguyen, Nicole R. Bush, Ginger L. Milne, Thomas F. McElrath, Shanna H. Swan, Kelly K. Ferguson

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background: Oxidative stress has been implicated in numerous birth outcomes, including spontaneous preterm birth. However, the relationship with presentation at delivery has been less well studied. We assessed the relationship between oxidative stress biomarkers and gestational duration with a focus on spontaneous presentation for delivery. Methods: Our sample included 740 women from a multi-center prospective cohort study, recruited from 2010 to 2012. Resultant measures of oxidative stress in pregnancy prostaglandin F (PGF), 8-iso-prostaglandin F (8-iso-PGF), and the primary 8-iso-PGF metabolite were measured in third trimester urine samples. Information on presentation for delivery was abstracted from medical records. We examined associations with preterm birth using adjusted logistic models. Time to event (overall delivery and spontaneous delivery) was examined using adjusted accelerated failure time models. Results: The 8-iso-PGF metabolite was associated with increased odds of overall preterm birth (OR: 1.44 [95% CI: 1.00, 2.06]), and the association with spontaneous preterm birth was similar in magnitude but not statistically significant (OR: 1.45 [95% CI: 0.96, 2.20]). We did not detect associations between other biomarkers and preterm birth, or between biomarkers and timing of overall or spontaneous delivery in accelerated failure time models. Conclusions: Our data suggest that increased oxidative stress, as indicated by the 8-iso-PGF metabolite, may be associated with preterm birth. In contrast to previous studies, associations were similar among individuals with spontaneous versus non-spontaneous presentation for delivery.

Original languageEnglish (US)
Pages (from-to)419-425
Number of pages7
JournalFree Radical Biology and Medicine
StatePublished - Jan 2019

Bibliographical note

Funding Information:
This research was supported by the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (NIEHS; ZIA103313 PI: K. Ferguson) and by the NIEHS grant R01 ES016863-04 .

Publisher Copyright:
© 2018


  • Isoprostanes
  • Oxidative stress
  • Preterm birth
  • Prostaglandin
  • Spontaneous labor


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