Keyphrases
Metabolism
100%
Metabolic Profiling
100%
Urinary Metabolites
100%
Cytochrome P450 1A2 (CYP1A2)
100%
Aminoflavone
100%
Cytochrome P450 1A1 (CYP1A1)
20%
P450s
20%
Cell Culture
10%
Tumor Cells
10%
Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS)
10%
Antiproliferative Activity
10%
Null Mice
10%
Metabolic Pathway
10%
Species Differences
10%
Incubation
10%
Major Contributor
10%
Monooxygenase
10%
Catalytic Activity
10%
Metabolic Activation
10%
Glucuronide
10%
Relative Composition
10%
In Vitro Metabolism
10%
Glucuronide Conjugate
10%
Sulfate Conjugates
10%
Fragmentation Pattern
10%
Selective Cytotoxicity
10%
Microsomal Incubation
10%
Liver Microsomes
10%
Drug-metabolizing Enzymes
10%
Accurate Mass Measurement
10%
Regioselective Oxidation
10%
Mass Spectrometry Fragmentation
10%
Humanized Mice
10%
Mouse Urine
10%
Comprehensive Map
10%
Structural Identity
10%
CYP2C
10%
Enzyme Kinetic Analysis
10%
Pooled Human Liver Microsomes
10%
Culture-based
10%
Pharmacology, Toxicology and Pharmaceutical Science
CYP1A2
100%
Mouse
75%
Glucuronide
50%
Cytochrome P450 1A
50%
Cytotoxicity
25%
Cell Culture
25%
Bioactivation
25%
Sulfate
25%
Knockout Mouse
25%
Enzyme Kinetics
25%
Antiinfective Agent
25%
Unspecific Monooxygenase
25%
Drug Metabolizing Enzyme
25%
Cytochrome P450 2C
25%
Neoplasm
25%
Immunology and Microbiology
Metabolite
100%
Liver Microsome
50%
Mouse
50%
Wild Type
50%
Liquid Chromatography Tandem Mass Spectrometry
25%
Humanized Mouse
25%
Cell Culture
25%
Metabolism
25%
Kinetics
25%
Knockout Mouse
25%
Cytotoxicity
25%
Tumor Cell
25%
Enzyme Kinetics
25%
Chemistry
Metabolite
100%
Metabolic
75%
Structure
25%
Phase Composition
25%
Kinetic Method
25%
Antiproliferative
25%
Monooxygenase
25%
Enzyme Kinetics
25%
Liquid Chromatography Tandem Mass Spectrometry
25%
Sulfate
25%