Ureterosigmoidostomy associated signet ring colon cancer presenting as hip pain

Rohtesh S. Mehta, Peter Ennis, Joseph Whitten

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Purpose: We present a case of a young male with a history of ureterosigmoidostomy who presented with hip pain, the subsequent workup of which revealed metastatic bone lesions from a primary sigmoid signet ring cell adenocarcinoma. Methods: Review of literature was conducted using databases PubMed Medline (1966-current), PubMed Central (1970-current), and EMBASE (1988-2009) to explore previous studies on the topic; used the Surveillance, Epidemiology and End Results Program for epidemiological data; and used the National Comprehensive Cancer Network guidelines for management recommendations. Results: Ureterosigmoidostomy is well-documented risk factor for colonic neoplasms, the reported incidence being 2-41% with a latent period of 10 to 30 years and a risk of occurrence 80-7,000 times higher than in the general population. The most common histological type of colon cancer seen after ureterosigmoidostomy is adenocarcinoma, but cases of signet-ring cell carcinoma have also been described. Signet-ring cell adenocarcinoma occurs predominantly in stomach but may infrequently arise from other organs such as breast, urinary bladder, and small and large bowel. Conclusions: This case underscores the importance of prolonged screening in patients with ureterosigmoidostomies and also calls for heightened awareness among primary care physicians regarding long-term risks associated with this unique entity.

Original languageEnglish (US)
Pages (from-to)122-127
Number of pages6
JournalJournal of Gastrointestinal Cancer
Volume43
Issue number1
DOIs
StatePublished - Mar 2012

Bibliographical note

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • adenocarcinoma
  • colon adenocarcinoma
  • colon cancer
  • hip pain
  • signet ring colon cancer
  • uretero-colic anastomosis
  • ureterosigmoidostomy

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