A series of urea compounds based on the tripeptide Phe-Trp-Lys were synthesized and pharmacologically characterized at the mouse melanocortin receptors. The results include identification of novel melanocortin receptor agonists with potencies ranging from nanomolar to micromolar.
Bibliographical noteFunding Information:
This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Fund Career Award in the Biomedical Sciences. Special thanks to Jim Rocca, McKnight Brain Institute, University of Florida for help with NMR spectroscopy.
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