Urea small molecule agonists on mouse melanocortin receptors

Christine G. Joseph, Rayna M. Bauzo, Zhimin Xiang, Carrie Haskell-Luevano

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A series of urea compounds based on the tripeptide Phe-Trp-Lys were synthesized and pharmacologically characterized at the mouse melanocortin receptors. The results include identification of novel melanocortin receptor agonists with potencies ranging from nanomolar to micromolar.

Original languageEnglish (US)
Pages (from-to)2079-2082
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number12
DOIs
StatePublished - Jun 16 2003

Bibliographical note

Funding Information:
This work has been supported by NIH Grant RO1-DK57080. Carrie Haskell-Luevano is a recipient of a Burroughs Wellcome Fund Career Award in the Biomedical Sciences. Special thanks to Jim Rocca, McKnight Brain Institute, University of Florida for help with NMR spectroscopy.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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