In the present study, urea, a well-known adductor for linear compounds was successfully utilized for inclusion of glipizide-a highly substituted cyclic organic compound through a modified technique. Formation of glipizide co-inclusion compounds in urea was confirmed by FTIR, DSC and XRD. The minimum proportion of rapidly adductible endocyte (RAE) required for adduction of glipizide in urea was estimated by a modified Zimmerschied calorimetric method. Urea-GLP-RAE inclusion compounds containing varying proportions of guests were prepared and their thermal behaviour studied by DSC. The co-inclusion compounds were found to exhibit good content uniformity. Through the formation of co-inclusion compounds of urea, it was possible to achieve steep improvement in the dissolution efficiency of glipizide, which is a BCS class II drug.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Inclusion Phenomena and Macrocyclic Chemistry|
|State||Published - Apr 1 2008|
- Content uniformity
- Dissolution rate
- Urea inclusion compounds