Urea co-inclusion compounds of glipizide for the improvement of dissolution profile

Seema Thakral, A. K. Madan

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

In the present study, urea, a well-known adductor for linear compounds was successfully utilized for inclusion of glipizide-a highly substituted cyclic organic compound through a modified technique. Formation of glipizide co-inclusion compounds in urea was confirmed by FTIR, DSC and XRD. The minimum proportion of rapidly adductible endocyte (RAE) required for adduction of glipizide in urea was estimated by a modified Zimmerschied calorimetric method. Urea-GLP-RAE inclusion compounds containing varying proportions of guests were prepared and their thermal behaviour studied by DSC. The co-inclusion compounds were found to exhibit good content uniformity. Through the formation of co-inclusion compounds of urea, it was possible to achieve steep improvement in the dissolution efficiency of glipizide, which is a BCS class II drug.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
Volume60
Issue number3-4
DOIs
StatePublished - Apr 1 2008

Keywords

  • Adduction
  • Complexation
  • Content uniformity
  • Dissolution rate
  • Glipizide
  • Urea inclusion compounds

Fingerprint Dive into the research topics of 'Urea co-inclusion compounds of glipizide for the improvement of dissolution profile'. Together they form a unique fingerprint.

  • Cite this