Uptake of ozone in human lungs and its relationship to local physiological response

Wade H. Reeser, Genea M. Lee, Adekemi Taylor, Lan Wang, Steve F. Arnold, James S. Ultman, Abdellaziz Ben-Jebria

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3 Scopus citations


To investigate whether intersubject variations in the dose of inhaled ozone (O3) cause corresponding variations in the physiological response, 28 female and 32 male nonsmokers participated in a 1-h continuous inhalation of clean air or 0.25 ppm O3 while exercising on a cycle ergometer at a constant ventilation rate of 30 L/min. The exposure protocols included continuous monitoring of respiratory flow rate and O3 concentration from which O3 uptake (OZU) and fractional uptake efficiency (UE) were computed. Pre-to-post changes in forced expired volume in 1 s (%ΔFEV 1), peripheral cross section for carbon dioxide diffusion (%ΔAP), and Fowler dead space volume (VD) were also measured for each exposure. Individual values of UE ranged from .70 to .98 among all the subjects, with significant differences (p<.05) existing between men and women. These intersubject differences were inversely correlated with breathing frequency and directly correlated with tidal volume. The mean ± SD values of %ΔFEV1, %ΔAP, and %ΔV D were all significantly more negative in the O3 exposure session (-13.31 ± 13.40, -8.14 ± 7.62, and -4.20 ± 5.12, respectively) than in the air exposure session (-0.06 ± 4.56, 0.22 ± 10.82, and -0.70 ± 6.88, respectively). Finally, our results showed that neither %ΔFEV1 nor %ΔVD was correlated OZU, whereas there was a significant relationship (ρ = -0.325, p = .0257) between %ΔAP and OZU. We conclude that the overall uptake of O3 is a weak predictor of intersubject variations in distal airspace response, but is not a predictor of intersubject variations in conducting airway responses.

Original languageEnglish (US)
Pages (from-to)699-707
Number of pages9
JournalInhalation Toxicology
Issue number13
StatePublished - Dec 1 2005


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